摘要
C/EBP(CCAAT enhancer binding protein)同源蛋白(CHOP)通过显性负调控的方式抑制转录因子C/EBP和肝富集转录激活蛋白(LAP)。CHOP是内质网应激介导的细胞凋亡通路中重要的中间信号分子。本文综述了CHOP蛋白的分子特征;CHOP在细胞凋亡,自噬和焦亡中参与的信号通路及调控作用;CHOP在内质网应激引发的缺血再灌注相关的肾脏、肝脏功能损伤、炎症、帕金森、糖尿病、肿瘤等疾病中发挥的重要调控作用,为临床上多种疾病的诊断与治疗提供新的靶点,扩展新的思路。
C/EBP(CCAAT enhancer binding protein)homologous protein(CHOP)inhibits the transcription factor C/EBP and liver-enriched transcriptional activator protein(LAP)through a dominant negative regulation.CHOP is an important intermediate signal molecule in the apoptosis pathway mediated by endoplasmic reticulum stress.This article reviews the molecular characteristics of CHOP protein,the signal pathway and regulation of CHOP in apoptosis,autophagy,and pyroptosis.CHOP plays an important regulatory role in kidney,liver damage,inflammation,parkinsonism,diabetes,tumors,and other diseases related to ischemia-reperfusion caused by endoplasmic reticulum stress,providing new targets for the diagnosis and treatment of a variety of clinical diseases.
作者
段卓
苏振宏
方大维
谢小林
解举民
DUAN Zhuo;SU Zhenhong;FANG Dawei;XIE Xiaolin;XIE Jumin(Medical College of Hubei Polytechnic University,Huangshi,Hubei,China,435003;Hubei Key Laboratory of renal Disease Occurrence and Intervention,Hubei Polytechnic University,Huangshi,Hubei,China,435003;General Surgery Department,Huangshi Second People's Hospital,Huangshi,Hubei,China,435000;Medical Department,Huangshi Psychiatric Hospital,Huangshi,Hubei,China,435003)
出处
《分子诊断与治疗杂志》
2021年第1期165-168,共4页
Journal of Molecular Diagnostics and Therapy
基金
湖北省自然科学基金(2018CFB406)
湖北理工学院人才引进项目(19XJK02R)。
