高频振荡通气治疗重症新生儿呼吸窘迫综合征疗效分析

Analysis of the effect of high frequency oscillatory ventilation on severe illness newborn respiratory distress syndrome

目的探讨高频振荡通气治疗重症新生儿呼吸窘迫综合征的临床疗效。方法选取2018年2月至2019年10月本院收治的100例重症新生儿呼吸窘迫综合征患儿为研究对象,根据随机数字表法分为两组,每组50例。对照组采取常频机械通气治疗,实验组采取高频振荡通气治疗。比较两组患儿临床疗效、血气指标、上机时间、氧疗时间、住院时间及并发症发生率。结果实验组总有效率(94.00%)高于对照组(70.00%),差异有统计学意义(P<0.05)。治疗前,两组PaO2、PaCO2指标比较差异无统计学意义;治疗后,实验组PaO2指标高于对照组,PaCO2指标低于对照组,差异有统计学意义(P<0.05)。实验组并发症发生率(6.00%)低于对照组(22.00%),差异有统计学意义(P<0.05)。实验组上机时间、氧疗时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。结论高频振荡通气治疗重症新生儿呼吸窘迫综合征临床疗效显著,可明显改善血气指标,缩短治疗时间,减少并发症发生情况,值得临床推广应用。

Objective To investigate the clinical efficacy of high-frequency oscillatory ventilation in the treatment of severe illness newborn respiratory distress syndrome.Methods 100 cases of severe illness newborn respiratory distress syndrome admitted to our hospital from February 2018 to October 2019 were selected as the research subjects,and they were divided into two groups according to the random number table method,with 50 cases in each group.The control group was treated with regular-frequency mechanical ventilation,and the experimental group was treated with high-frequency oscillatory ventilation.The clinical efficacy,blood gas indexes,time on computer,time of oxygen therapy,length of hospital stay and occurrence of complications rate were compared between the two groups.Results The total effective rate of the experimental group(94.00%)was higher than that of the control group(70.00%),and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in PaO2 and PaCO2 between the two groups;after treatment,the PaO2 index of the experimental group was higher than that of the control group,and the PaCO2 index was lower than that of the control group,the difference was statistically significant(P<0.05).The complication rate of the experimental group(6.00%)was lower than that of the control group(22.00%),the difference was statistically significant(P<0.05).The time on computer,the time of oxygen therapy,and the length of stay in the experimental group were shorter than those of the control group,and the difference was statistically significant(P<0.05).Conclusion High-frequency oscillatory ventilation has a significant clinical effect in the treatment of severe illness newborn respiratory distress syndrome.It can significantly improve blood gas indicators,shorten treatment time,and reduce complications.It is worthy of clinical application.