IL-6、TNF-α、CRP在急性脑梗死患者血清中的表达变化

Study on the Expression Changes of IL-6, TNF-α and CRP in Serum of Patients with Acute Cerebral Infarction

目的探讨IL-6、TNF-α、CRP在急性脑梗死患者血清中的表达变化情况。方法选取2018年2月至2019年11月到本院就诊的80例急性脑梗死患者作为观察组,选取同期进行体检的80名健康者作为对照组。观察组患者中又划分为大、中、小灶组,分别为23例、26例、31例,对比两组白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)水平以及不同病灶组IL-6、TNF-α、CRP的表达水平。结果观察组血清IL-6、TNF-α、CRP表达水平显著高于对照组(P <0.05)。大灶组IL-6、CRP表达水平显著高于中、小灶组,中灶组IL-6、CRP表达水平显著高于小灶组(P <0.05);大灶组TNF-α水平显著高于中、小灶组,中灶组TNF-α水平显著高于小灶组(P <0.05)。结论在急性脑梗死发病过程中,IL-6、TNF-α、CRP水平具有高表达,随着患者病情的逐渐好转,炎性细胞因子水平会逐渐降低。临床可将IL-6、TNF-α、CRP水平作为诊断和治疗急性脑梗死疾病患者的重要依据。

Objective To investigate the changes of IL-6, TNF-α and CRP in serum of patients with acute cerebral infarction. Methods A total of 80 patients with acute cerebral infarction and 80 healthy people who had physical examination at the same time from February 2018 to November 2019 were selected as the research targets. The former was set as the observation group and the latter as the control group. Patients in the observation group were further divided into large, medium and small focus groups, with 23 cases, 26 cases and 31 cases respectively. The levels of IL-6, TNF-α and CRP in the two groups were compared, as well as the levels of IL-6, TNF-α and CRP in different focus groups. Results The levels of serum IL-6, TNF-α and CRP in the observation group were significantly higher than those in the control group(P<0.05). The expression levels of IL-6 and CRP in the large focus group were significantly higher than those in the medium and small focus groups. The expression levels of IL-6 and CRP in the medium focus group were significantly higher than those in the small focus group(P <0.05);the TNF-α levels in the large focus group were significantly higher than those in the medium and small focus groups in the middle focus group, the level of TNF-α was significantly higher than that of the small focus group(P<0.05). Conclusion The levels of IL-6, TNF-α and CRP are highly expressed in the pathogenesis of acute cerebral infarction, and the levels of inflammatory cytokines will gradually decrease with the gradual improvement of patients’ condition. Therefore, the determination of IL-6, TNF-α and CRP plays an important role in the diagnosis and treatment of acute cerebral infarction diseases, which should be paid more attention to in clinic.