布地奈德福莫特罗结合无创通气治疗呼吸衰竭的效果观察

Observation on the Effect of Budesonide Formoterol Combined with Non-invasive Ventilation in the Treatment of Respiratory Failure

目的分析联合治疗手段(布地奈德福莫特罗+无创通气)治疗呼吸衰竭的可行性和临床疗效,为呼吸衰竭治疗提供参考。方法选择我院2019年7月至2020年4月诊治的80例呼吸衰竭患者,随机法分为对照组(n=40)与联合组(n=40),分别应用常规治疗、无创通气配合布地奈德福莫特罗治疗。比较两组呼吸衰竭患者治疗后临床疗效、肺功能改善情况。结果两组患者治疗前第1秒用力呼气容积(forced expiratory volume in one second,,FEV1)、第1秒用力呼气量占用力肺活量比值(the ratio of forced expiratory volume in the first secondt of orced vital capacity,FEV1/FVC)、FEV1占预计值百分比(FEV1predicted,FEV1%)比较,差异无显著性(P> 0.05);治疗后FEV1、FEV1/FVC、FEV1%较治疗前均有所改善,且联合组上述指标均优于对照组(P <0.05);联合组总有效率高于对照组(P <0.05)。结论无创通气治疗呼吸衰竭的基础上配合布地奈德福莫特罗治疗可以促进患者肺功能改善,提升临床治疗效果,有助于患者生活质量提升。

Objective To analyze the feasibility and clinical efficacy of combined treatment(budesonide formoterol + non-invasive ventilation) in the treatment of respiratory failure, and to provide references for the treatment of respiratory failure. Methods Eighty patients with respiratory failure diagnosed and treated in our hospital from July 2019 to April 2020 were randomly divided into a control group(n=40) with conventional treatment and combination group(n=40) with a combination of non-invasive ventilation and budesonide formoterol. The clinical efficacy and improvement of lung function after treatment were compared between the two groups of patients with respiratory failure. Results Forced expiratory volume in one second(FEV1), the ratio of forced expiratory volume in the first second to forced vital capacity,(FEV1/FVC) and FEV1 predicted(FEV1%), the difference is not significant(P>0.05);FEV1, FEV1/FVC, FEV1% after treatment are all improved compared to before treatment, and the above indicators of the combination group were better than those of the control group(P <0.05);the total effective rate of the combined group was higher than that of the control group(P <0.05). Conclusion On the basis of non-invasive ventilation in the treatment of respiratory failure, combined with budesonide formoterol therapy can promote the improvement of patients’ lung function, improve clinical treatment effect, and help patients improve their quality of life.