微生态制剂干预预防肺癌PICC置管化疗患者血栓及对患者血液相关指标和炎性因子水平的影响

Preventive effects of microecological agent intervention on thrombosis in patients with lung cancer undergoing chemotherapy with PICC catheterization and its influences on blood related indicators and inflammatory factors level

目的:探讨微生态制剂干预对肺癌PICC置管化疗患者血栓的预防作用及对患者血液相关指标和炎性因子水平的影响。方法:收集96例肺癌PICC置管化疗患者作为研究对象,回顾性分析其临床资料,按照是否给予微生态制剂干预分为对照组和观察组,每组各48例。对照组给予常规干预,观察组在对照组基础上给予微生态制剂干预(即给予双歧杆菌乳杆菌三联活菌片)。比较两组患者PICC相关血栓发生率、干预前后凝血相关指标、血液流变学指标及炎性因子水平。结果:干预后,与对照组相比,观察组PICC相关血栓发生率降低(8.3%vs 25.0%),组织因子、纤维蛋白原、D-Dimer凝血指标降低[(346.08±37.35)ng/L vs (403.98±42.71)ng/L、(2.46±0.65)g/L vs (2.78±0.79)g/L、(1.98±0.72)mg/L vs (2.48±0.84)mg/L],血浆黏度、红细胞压积、血沉血液流变学指标水平降低[(3.89±0.44)mPa·s vs (4.26±0.48)mPa·s、(43.73±3.58)%vs (47.59±3.72)%、(37.44±4.03) mm/h vs (41.67±4.31) mm/h],白细胞介素6 (IL-6)、C反应蛋白(CRP)炎性因子水平降低[(41.06±6.35) pg/mLvs (49.83±6.74) pg/mL、(5.86±1.34) mg/L vs (6.61±1.40) mg/L],组间比较均有统计学差异(P均<0.05)。结论:微生态制剂干预能够在一定程度上预防肺癌PICC置管化疗患者PICC相关血栓的发生,并且能够改善凝血、血液流变学指标,减轻机体炎性反应。

Objective:To investigate preventive effects of microecological agent intervention on thrombosis in patients with lung cancer undergoing chemotherapy with PICC catheterization and its influences on blood related indicators and inflammatory factors level.Methods:96 patients with lung cancer undergoing chemotherapy with PICC catheterization were collected as research objects.Their clinical materials were retrospectively analyzed.Those patients were divided into the control group and the observation group with 48 cases in each group according to whether microecological agent intervention were given.The control group was given conventional intervention.Besides that,the observation group was given microecological agent intervention,as lactobacillus bifidus triple viable tablets was given.Then,incidences of PICC-related thrombosis,levels coagulation related indices,hemorheological indices and inflammatory factors were compared between the two groups.Results:In comparison with the control group after intervention,the observation group had lower incidence of PICC-related thrombosis(8.3%vs 25.0%),lower levels of tissue factor,fibrinogen,D-Dimer[(346.08±37.35)ng/L vs(403.98±42.71)ng/L,(2.46±0.65)g/L vs(2.78±0.79)g/L,(1.98±0.72)mg/L vs(2.48±0.84)mg/L],lower levels of hemorheological indices of plasma viscosity,hematocrit,erythrocyte sedimentation rate[(3.89±0.44)mPa·s vs(4.26±0.48)mPa·s,(43.73±3.58)%vs(47.59±3.72)%,(37.44±4.03)mm/h vs(41.67±4.31)mm/h]and lower levels of inflammatory factors of interleukin 6(IL-6),C reactive protein(CRP)[(41.06±6.35)pg/mL vs(49.83±6.74)pg/mL,(5.86±1.34)mg/L vs(6.61±1.40)mg/L]with all statistical differences(all P<0.05).Conclusion:For patients with lung cancer undergoing chemotherapy with PICC catheterization,microecological agent intervention can prevent incidence of PICC-related thrombosis to an extent,and it can improve coagulation related indices,hemorheological indices and alleviate inflammatory reaction.