HPV阳性口咽癌的研究现状与进展

Research status and progress of HPV-positive oropharyngeal cancer

口咽癌是常见的头颈部恶性肿瘤之一,以鳞状细胞癌多见。既往,烟草和酒精被认为是导致口咽癌的主要原因。而近年来,欧美国家流行病学研究发现,随着对烟酒的把控,无烟酒嗜好的、与HPV感染相关的口咽癌患者反而较前增加。可见,HPV感染已成为导致口咽癌的一种新的危险因素,其在欧美国家口咽癌中的流行程度正在上升,且该类型患者与其他类型口咽癌患者相比,其疗效及预后也存在明显差异。这使得HPV感染与口咽癌的相关性越来越被国内外研究者和临床医生所重视。本文将HPV阳性口咽癌的发病机制、检测方式、预后与治疗等方面作一综述。

In recent years,epidemiological studies in European and American countries have found that the incidence of HPV-related oropharyngeal cancer without tobacco or alcohol habit is higher than before,and the treatment and prognosis of this type of patients are also significantly different from hpv-irrelated oropharyngeal cancer.This makes the relationship between HPV and oropharyngeal cancer more and more valued by researchers and clinicians.Therefore,This article reviews the pathogenesis,detection methods,prognosis and treatment of HPV-positive oropharyngeal cancer.