铁掺杂的聚2-硝基-1,4-苯二胺纳米球的制备及在光热/光动力/化学动力学肿瘤治疗中的应用

Ion-doped Poly(2-nitro-1,4-phenylenediamine)Nanospheres for Synergistic Photo-and Chemo-Dynamic Therapy

肿瘤微环境(TME)的复杂性,使得单一治疗方式很难实现完全治愈。为此,构建了一种负载吲哚菁绿(ICG)的铁掺杂的聚2-硝基-1,4-苯二胺多功能纳米球Fe-PNPD-ICG(FPIs),用于光热(PTT)/光动力(PDT)/化学动力学(CDT)的联合治疗。在808 nm激光器照射下,ICG作为光敏剂可以产生单线态氧,铁掺杂的聚2-硝基-1,4-苯二胺纳米球作为光热剂具有36.65%的光热转换效率。FPIs一旦内化到肿瘤内,由Fe 3+/Fe 2+转化引发Fenton反应产生·OH实现化学动力学治疗,反应过程中可以清除TME中过表达的谷胱甘肽(GSH),从而降低肿瘤中的抗氧化能力。同时,产生的氧气可以改善TME中乏氧情况,增强PDT的治疗效果。因此,FPIs是PTT/PDT/CDT联合治疗的一种理想材料,在肿瘤治疗中具有潜在的应用前景。

The complexity of the tumor microenvironment(TME)makes it difficult to completely eliminate tumors with a single treatment.Herein,ion-doped poly(2-nitro-1,4-phenylenediamine)multifunctional nanospheres loaded with indocyanine green(ICG)are constructed for synergistic cancer therapy by photothermal therapy(PTT)/photodynamic therapy(PDT)/chemo-dynamic therapy(CDT).Under 808 nm laser irradiation,ICG as a photosensitizer could generate 1 O 2 and Fe-PNPD acts as a photothermal agent with a photothermal conversion efficiency of 36.65%.Once Fe-PNPD-ICG(FPIs)is internalized into the cancer cells,it triggers the Fenton reaction to produce·OH,and clears the over-expressed glutathione(GSH)in TME,thereby reducing the antioxidant capacity in the tumor.At the same time,the generated oxygen can reduce hypoxia in TME and enhance the therapeutic effect of PDT.FPIs is an ideal candidate for synergistic PTT/PDT/CDT therapy,and has broad application prospects for tumor therapy.