组织miRNA指标在宫颈癌的表达情况及其与病理分型、组织分化的相关性研究

Study on the expression of tissue miRNA indicators in cervical cancer and its correlation with pathological typing and tissue differentiation

目的探讨组织miRNA指标在宫颈癌的表达及与病理分型及组织分化的相关性。方法选取2016年2月至2019年10月的60例宫颈癌患者作为观察组,同时选取60例健康同龄女性作为对照组。比较两组宫颈组织miRNA指标(miR-34a及miR-19a)表达水平,并探讨宫颈癌不同病理分型、组织分化程度及国际妇产科联合会(FIGO)分期与组织miRNA指标的相关性。结果观察组miR-34a表达水平低于对照组[(0.35±0.05)vs.(0.98±0.12)],miR-19a表达水平高于对照组[(3.75±0.39)vs.(1.02±0.23)],不同病理分型、组织分化程度及FIGO分期的miR-34a及miR-19a表达水平比较,差异有统计学意义(P<0.05)。相关性分析显示,miR-34a及miR-19a与病理分型明显相关,其中miR-34a与组织分化程度呈正相关、与FIGO分期呈负相关,miR-19a与组织分化程度呈负相关、与FIGO分期呈正相关(P<0.05)。结论组织miRNA指标在宫颈癌呈现异常表达,其与病理分型、组织分化有相关性。

Objective To explore the expression of tissue miRNA indicators in cervical cancer and its correlation with pathological classification and tissue differentiation.Methods Sixty patients with cervical cancer from February 2016 to October 2019 were selected as the observation group,while 60 healthy women of the same age were selected as the control group.The expression levels of miRNA indicators(miR-34a and miR-19a)in cervical tissues were compared between the two groups,and the correlation between different pathological types,tissue differentiation and international federation of gynecology and obstetrics(FIGO)stages of cervical cancer and tissue miRNA indicators was discussed.Results The expression level of miR-34a in the observation group was lower than that in the control group[(0.35±0.05)vs.(0.98±0.12)],and the expression level of miR-19a was higher than that in the control group[(3.75±0.39)vs.(1.02±0.23)],there were different statistical significant in the expression levels of miR-34a and miR-19a in different pathological types,tissue differentiation levels and FIGO stages(P<0.05).Correlation analysis showed that miR-34a and miR-19a were significantly correlated with pathological typing.Among them,miR-34a was positively correlated with the degree of tissue differentiation and negatively correlated with FIGO staging,while miR-19a was negatively correlated with the degree of tissue differentiation and positively correlated with FIGO staging(P<0.05).Conclusion Tissue miRNA indicators show abnormal expression in cervical cancer,which is related to pathological typing and tissue differentiation.