microRNA在炎症性皮肤病中作用的研究进展

Role of microRNAs in inflammatory skin diseases

microRNA(miRNA)是一类转录后调控基因表达的非编码RNA分子,参与皮肤各种病理生理过程。近年来,miRNA表达谱的变化已被报道与部分炎症性皮肤病相关,例如miR-203、miR-146a、miR-21在银屑病皮损中表达上调;miR-155、miR-146a在特应性皮炎皮损中表达上调;miR-21、miR-223、miR-142-3p、miR142-5p在过敏性接触性皮炎皮损表达上调;而miR-146a、miR-155在系统性红斑狼疮患者外周血表达下调;miR-223在皮肌炎皮损中表达下调等。本文综述miRNA与部分炎症性皮肤病发生、发展之间的联系。

MicroRNAs(miRNAs)are a class of non-coding RNA molecules that regulate gene expression after transcription and participate in various pathophysiological processes in the skin.In recent years,it has been reported that changes in miRNA expression profiles are related to some inflammatory skin diseases.For example,miR-203,miR-146a and miR-21 are upregulated in psoriatic lesions,miR-155 and miR-146a are upregulated in atopic dermatitis lesions,miR-21,miR-223,miR-142-3p and miR142-5p are upregulated in allergic contact dermatitis lesions;however,miR-146a and miR-155 are downregulated in peripheral blood of patients with systemic lupus erythematosus,and miR-223 is downregulated in dermatomyositis lesions.This review summarizes relationships of miRNAs with the occurrence and development of some inflammatory skin diseases.