瘦素、N-Cadherin在大肠癌中的表达及临床意义

Expression and Clinicopathological Significance of Leptin and N-Cadherin Expression in Patients with Colorectal Cancer

【目的】探讨瘦素、N-Cadherin蛋白表达与大肠癌临床病理特征之间的关系。【方法】采用免疫组织化学SP法检测蛋白瘦素、N-Cadherin在120例大肠癌中的表达并分析与临床病例资料的关系。【结果】瘦素、N-Cadherin在大肠癌中的阳性表达率分别为75.8%(91/120)和68.3%(82/120);瘦素与N-Cadherin的高表达均与大肠癌的浸润深度、临床分期、淋巴结转移、分化程度密切相关(P<0.05);大肠癌组织中瘦素、N-Cadherin的表达呈显著正相关,差异有统计学意义(P<0.01)。【结论】瘦素、N-Cadherin可能在大肠癌的发生、发展中起相互协同作用,二者可能作为判断大肠癌预后及指导临床治疗的指标。

【Objective】To investigate the relationship of leptin and N-Cadherin protein expression with clinicopathological features in colorectal cancer.【Methods】The expression of leptin and N-Cadherin protein was evaluated by immuno histochemistry in 120 cases of colorectal cancer.The relationship between the staining pattern and clinicopathogical features was analyzed.【Results】The positive rates of leptin and N-Cadherin protein in colorectal cancer were 75.8%(91/120)and 68.3%(82/120),respectively.The expression intensity of leptin and N-Cadherin protein was related to invasive depth,TNM stages,lymph node metastasis and tumor differentiation of colorectal cancer.The difference was statistically significant(P<0.05).In colorectal cancer tissues,the leptin expression was positively correlated with N-Cadherin expression;and the difference was statistically significant(P<0.001).【Conclusion】Leptin and N-Cadherin may play an important role in the occurrence and development of colorectal cancer.The detection of leptin and N-Cadherin may be helpful for the evaluation of prognosis and treatment for colorectal cancer patients.