人参五味子汤对支气管哮喘患儿外周血白细胞介素-8、白细胞介素-17、瘦素水平和肺功能的影响

Effects of Ginseng Schisandrae Decoction on Levels of Interleukin-8,Interleukin-17,Leptin in Peripheral Blood and Lung Function in Children with Bronchial Asthma

目的:探讨人参五味子汤治疗儿童支气管哮喘的临床疗效及其对肺功能、外周血白细胞介素(IL)-8、IL-17、瘦素水平的影响。方法:选取2017年12月至2018年12月山东第一医科大学第二附属医院儿科收治的5~14岁支气管哮喘患儿46例,采用随机数字表法分为对照组22例和治疗组24例,两组患儿均给予吸入性激素雾化,喘息加重时联合支气管扩张剂雾化,有细菌感染时加用抗菌药物,治疗组在此基础上加用人参五味子汤,连续服药3个月。观察两组患儿临床疗效,检测肺通气功能,酶联免疫吸附试验(ELISA)法检测外周血IL-8、IL-17、瘦素水平。结果:治疗后,治疗组控制率95.8%,对照组控制率为72.7%,差异有统计学意义(P<0.05)。治疗前,两组患儿第1秒用力呼气末容积(FEV1)、用力呼气流量(PEF)、外周血IL-8、IL-17、瘦素水平比较,差异均无统计学意义(P>0.05);治疗后,治疗组患儿FEV1、PEF水平较对照组升高(P<0.05),治疗组患儿IL-8、IL-17、瘦素水平较对照组降低(P<0.05)。结论:人参五味子汤可明显改善支气管哮喘患儿症状与体征,提高肺通气功能,同时可以降低IL-8、IL-17、瘦素水平。

Objective:To probe into the clinical efficacy of ginseng schisandrae decoction in the treatment of children with bronchial asthma and its effects on lung function,interleukin(IL)-8,IL-17 and leptin.Methods:A total of 46 children(from 5 to 14 years old)with bronchial asthma admitted into the Second Affiliated Hospital of Shandong First Medical University from Dec.2017 to Dec.2018 were extracted to be divided into the control group(n=22)and the treatment group(n=24)via the random number table.Both groups were given inhalation of hormone,atomization inhalation of bronchodilators during asthma exacerbation and antibiotics if infection existed.In the treatment group,ginseng schisandrae decoction was given on this basis for 3 months.Clinical efficacy of both groups was observed,lung ventilation function was detected,and the levels of IL-8,IL-17 and leptin in peripheral blood were detected by enzymelinked immunosorbent assay(ELISA).Results:After treatment,the control rate was 95.8% in the treatment group and 72.7% in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the first second forced end-expiratory volume(FEV1),peak expiratory flow(PEF),IL-8,IL-17 and leptin in peripheral blood between two groups(P>0.05).After treatment,FEV1 and PEF in the treatment group were higher than those in the control group(P<0.05),while the levels of IL-8,IL-17 and leptin in the treatment group were lower than those in the control group(P<0.05).Conclusion:Ginseng schisandrae decoction can significantly improve the symptoms and signs in children with bronchial asthma,improve the lung function,and reduce the levels of IL-17,IL-8 and leptin.