不同温度布地奈德+沙丁胺醇雾化液辅助治疗儿童毛细支气管炎疗效比较

Comparison of Efficacy of Budesonide and Salbutamol Aerosol Inhalation at Different Temperatures in Adjuvant Treatment of Children with Bronchiolitis

目的:比较不同温度布地奈德+沙丁胺醇雾化液辅助治疗儿童毛细支气管炎的临床疗效。方法:选取2018年6-12月在我院就诊的毛细支气管炎患儿100例,随机分为对照组和观察组各50例。两组患儿均在常规治疗基础上加用雾化治疗:对照组采用常规温度22~24℃的布地奈德+沙丁胺醇雾化液,观察组采用35~37℃的布地奈德+沙丁胺醇雾化液。观察两组患儿的临床症状消失时间及住院时间,比较两组患儿治疗前后的肺功能指标、血清降钙素原(PCT)及C反应蛋白(CRP)水平,分析两组患儿的疗效及不良反应发生情况。结果:观察组患儿的临床症状消失时间及住院时间短于对照组,治疗5 d后肺功能指标优于对照组,血清PCT及CRP水平低于对照组(P均<0.05)。观察组治疗5 d后总有效率高于对照组(P<0.05),两组患儿在治疗过程中均未出现明显不良反应。结论:与常规温度22~24℃相比,采用35~37℃的布地奈德+沙丁胺醇雾化液辅助治疗儿童毛细支气管炎疗效更显著,能快速缓解临床症状体征,且无明显不良反应。

Objective:To compare the clinical efficacy of budesonide and salbutamol aerosol inhalation at different temperatures in adjuvant treatment of children with bronchiolitis.Methods:Totally 100 children with bronchiolitis admitted into our hospital from Jun.to Dec.2018 were extracted to be randomly divided into the control group and the observation group,with 50 cases in each group.Both groups were treated with aerosol inhalation on the basis of conventional treatment.The control group was treated with budesonide and salbutamol aerosol inhalation at the conventional temperature from 22℃ to 24℃,and the observation group received budesonide and salbutamol aerosol inhalation at temperature from 35℃ to 37℃.Disappearance time of clinical symptoms and length of stay were observed.Lung function indexes,serum procalcitonin(PCT)and C-reactive protein(CRP)levels of two groups were compared before and after treatment.The treatment effects and incidence of adverse drug reactions of two groups were compared.Results:The disappearance time of clinical symptoms and the length of stay in the observation group were shorter than those in the control group.After 5 d of treatment,the pulmonary function indexes were better than those in the control group,and the levels of serum PCT and CRP were lower than those in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group after 5 d of treatment(P<0.05),there were no obvious adverse drug reactions in two groups.Conclusion:Compared with the conventional temperature from 22℃ to 24℃,the adjunctive treatment budesonide and salbutamol aerosol inhalation at temperature from 35℃ to 37℃ for children with bronchiolitis is more effective,which can quickly relieve the clinical symptoms and signs,with few adverse drug reactions.