DNA甲基化修饰在甲状腺癌中的研究进展

Research progress of DNA methylation in thyroid cancer

甲状腺癌是常见的内分泌系统恶性肿瘤,目前的研究发现甲状腺癌的发生与基因突变和表观遗传学改变有关。DNA甲基化是重要的表观遗传修饰之一,在调节甲状腺癌的进展中发挥着关键作用。随着表观遗传学研究的不断深入,DNA甲基化有望被开发为甲状腺癌诊断、预后和治疗应用方面的临床生物标志物。现对近年来DNA甲基化在甲状腺癌中的研究进展进行综述。

Thyroid cancer is a common malignant tumor of the endocrine system.Current studies have found that the occurrence of thyroid cancer is related to gene mutation and epigenetic changes.DNA methylation is one of the important epigenetic modifications,which plays a key role in regulating the progression of thyroid cancer.With the deepening of epigenetics research,DNA methylation is expected to be developed as a clinical biomarker for the diagnostic,prognostic and therapeutic application of thyroid cancer.This article summarizes the research progress of DNA methylation in thyroid cancer in recent years.