人表皮生长因子受体2、增殖细胞核抗原表达与乳腺癌患者病理特征相关性分析

Correlation between Expression of Human Epidermal Growth Factor Receptor 2,Proliferating Cell Nuclear Antigen and Pathological Features of Breast Cancer Patients

目的:探讨人表皮生长因子受体2(HER-2)、增殖细胞核抗原(Ki67)表达与乳腺癌患者病理特征的相关性。方法:选取某院乳腺癌患者98例(2018年4月~2019年4月),均行Ki67、HER-2检测,分析HER-2、Ki67阳性率及与乳腺癌患者病理特征(TNM分期)的相关性。结果:乳腺癌Ⅰ、Ⅱ、Ⅲ期Ki67阳性率为57.89%、79.17%、50.00%,HER-2阳性率为55.26%、85.42%、91.67%(P<0.05),Ki67、HER-2与乳腺癌TNM分期均呈正相关(P<0.05)。结论:HER-2、Ki67与乳腺癌患者病理特征有相关性,有助于乳腺癌恶性程度评估。

Objective:To investigate the correlation between the expression of human epidermal growth factor receptor 2(HER-2)and proliferating cell nuclear antigen(Ki67)and the pathological features of breast cancer patients.Methods:A total of 98 patients with breast cancer in a hospital(April 2018~April 2019)were enrolled in the study,and the Ki67 and Her-2 of patients were detected.The correlation of positive rate of HER-2 and Ki67 and the pathological features of breast cancer patients(TNM staging)were analyzed.Results:The positive rate of Ki67 in stage I,II and III of breast cancer was 57.89%,79.17%,50.00%,and the positive rate of HER-2 was 55.26%,85.42%,91.67%(P<0.05).Ki67,HER-2 was positively correlated with TNM stages of breast cancer(P<0.05).Conclusion:HER-2 and Ki67 are associated with the pathological features of breast cancer patients,which is helpful to evaluate the malignancy of breast cancer.