肾综合征出血热感染患者治疗中干扰素联合维拉帕米对血清细胞因子的影响分析

Analysis of the Effect of Interferon Combined with Verapamil on Serum Cytokines in Patients with Hemorrhagic Fever with Renal Syndrome

目的:研究肾综合征出血热感染患者治疗中干扰素联合维拉帕米对血清细胞因子的影响。方法:研究对象为2019年1月~2020年1月入院的70例肾综合征出血热感染患者,参考随机数字表法分为对照组和研究组各35例,对照组单用干扰素治疗,研究组联用干扰素与维拉帕米治疗,比较两组治疗前后血清细胞因子(白细胞介素-6、白细胞介素-10、肿瘤坏死因子-a)、血肌酐及血尿素氮水平。结果:研究组较对照组治疗后白细胞介素-6、白细胞介素-10与血肌酐、血尿素氮水平更低,肿瘤坏死因子-a水平更高(P<0.05)。结论:肾综合征出血热感染患者治疗中干扰素联合维拉帕米的应用效果显著,可有效改善患者血清细胞因子水平,改善肾功能。

Objective:To research the effect of interferon combined with verapamil on serum cytokines in patients with hemorrhagic fever with renal syndrome.Methods:70 patients with hemorrhagic fever with renal syndrome admitted to a hospital from January 2019 to January 2020 were selected and divided into the control group and study group by the random number table method,with 35 cases in each group.The control group was treated with interferon alone,and the study group was treated with interferon combined with verapamil;The serum cytokines(interleukin-6,interleukin-10,tumor necrosis factor-a),serum creatinine and blood urea nitrogen levels were compared between the two groups before and after treatment.Results:Compared with the control group,the study group had lower levels of interleukin-6,interleukin-10,blood creatinine,and blood urea nitrogen,and higher levels of tumor necrosis factor-a(P<0.05).Conclusion:The application of interferon combined with verapamil in the treatment of patients with hemorrhagic fever with renal syndrome has significant effect,which can effectively improve the serum cytokine levels of patients and improve renal function.