新疆地区2443例淋巴瘤构成比及临床特征分析

Constituent ratio and clinical characteristics of 2443 cases of lymphoma in Xinjiang

目的收集新疆医科大学第一附属医院病理科10年间2443例淋巴瘤病例,通过分析其病理类型、年龄及性别分布,为今后新疆地区淋巴瘤的流行病学研究提供基础。方法根据2016年WHO淋巴造血系统肿瘤分类标准,对2443例淋巴瘤病例进行光镜下观察,组织学分型。结果 (1)2443例淋巴瘤中,2183例(89%)为非霍奇金淋巴瘤(NHL),260例(11%)为霍奇金淋巴瘤(HL)。NHL 84%为B细胞淋巴瘤,16%为T细胞淋巴瘤。(2)HL中,一类为经典霍奇金淋巴瘤(CHL),以结节硬化型(133,51%)和混合细胞型(87,33%)为主要亚型,其次为富于淋巴细胞型和淋巴细胞消减型,另一大类为结节性淋巴细胞为主型霍奇金淋巴瘤(NLPHL)。(3)性别分布为男性1491例(61%),女性952例(39%)。HL男性173例,女性87例,平均年龄26岁,中位年龄22岁。结论新疆2443例淋巴瘤组织学类型以NHL为主,HL发病率高于欧美及其他国家,以维吾尔族居多,且与EB病毒感染密切相关。

Objective 2443 cases of lymphoma were collected in the Department of Pathology of the First Affiliated Hospital of Xinjiang Medical University during the past 10 years. The pathological types, age and sex distribution were analyzed in order to provide a basis for the epidemiological study of lymphoma in Xinjiang. Methods According to 2016 WHO lymphatic hematopoietic system tumor classification criteria, the 2443 cases of lymphoma collected in 10 years were observed under light microscope and histological types were classified. Results(1)Of the 2443 cases, 2183 cases(89%)were classified as Non-Hodgkin lymphoma(NHL)and 260 cases(11%)were classified as Hodgkin lymphoma(HL). 84% of NHL were B cell lymphoma, and 16% cases were T cell lymphoma.(2)Nodular sclerosis(133,51%) and Mixed cellularity(87,33%) are the main types in classical Hodgkin lymphoma(CHL), the others are lymphocyte-rich and lymphocyte-depleted, the another type is nodular lymphocytic Hodgkin lymphoma(NLPHL).(3)1491 cases(61%)were male and 952 cases(39%)were female. HL patients are 173 males and 87 females, mean age 26 years, median age 22 years.Conclusions The histological types of 2443 cases of lymphoma in Xinjiang were mainly NHL. The incidence of Hodgkin lymphoma in Xinjiang is higher than that of European and American countries and other nationalities, the majority is Uyghurs and is closely related to EBV infection.