基于中医传承辅助系统的张涤教授治疗儿童哮喘急性发作期组方用药经验挖掘

Exploration on Professor Zhang Di's Medication Experience on Asthma Acute Stage of Children Based on Inheritance of Traditional Chinese Medicine Auxiliary System

目的基于中医传承辅助平台(V2.5)挖掘分析张涤教授治疗儿童哮喘急性发作期的医案,总结其用药规律及临床经验,以便于中药新药的开发和名医经验传承。方法整理收集2019年8月至2020年1月于张涤教授门诊就诊的哮喘急性发作期患儿医案,筛选出292首处方,将相关资料录入中医传承辅助平台软件,通过平台软件内置的一般统计、文本挖掘、关联规则、复杂系统熵方法及熵层次聚类法等相关分析方法进行基本情况统计和用药规律挖掘分析。结果292首处方中所用到的中药共84味,多入肺、脾、胃经。其中提取出了15味关键药物,依次是桑白皮、桔梗、地骨皮、茯苓、白前、百部、紫苏子、白果、杏仁、蜜麻黄、款冬花、甘草、紫菀、鸡内金、山楂炭。提取出14组核心药物组合和7个新处方组合。结论张涤教授治疗儿童哮喘急性发作期以化痰止咳、降气平喘为主,兼顾健脾扶正。

Objective Based on the traditional Chinese medicine inheritance auxiliary platform(V2.5),the medical records of professor Zhang Di in the treatment of asthma acute stage in children were analyzed,and the medication regularity and clinical experience were summarized,so as to facilitate the development of new traditional Chinese medicine and the inheritance of famous doctors'experience.Methods The medical records of children with asthma acute stage in the outpatient department of professor Zhang Di from August 2019 to January 2020 were collected,292 prescriptions were selected,the relevant data were input into the software of traditional Chinese medicine inheritance auxiliary platform,and the basic situation statistics and medication law mining analysis were carried out through the platform software built-in general statistics,text mining,association rules,complex system entropy method and entropy hierarchical clustering method.Results A total of 84 herbs were used in 292 prescriptions,most of which entered the lung,spleen and stomach meridians.Among them,15 key drugs were extracted,which were Sangbaipi(Mori Cortex),Jiegeng(Platycodonis Radix),Digupi(Lycii Cortex),Fuling(Poria),Baiqian(Cynanchi Stauntonii Rhizoma ET Radix),Baibu(Stemonae Radix),Zisuzi(Perillae Fructus),Baiguo(Ginkgo Semen),Kuxingren(Armeniacae Semen Amarum),Mimahuang(Ephedrae Herba),Kuandonghua(Farfarae Flos),Gancao(Glycyrrhizae Radix Et Rhizoma),Ziwan(Asteris Radix Et Rhizoma),Jineijin(Galli Gigerii Endothelium Corneum)and Shanzhatan(Charred Crataegus).14 core drug combinations and 7 new prescription combinations were extracted.Conclusion Professor Zhang Di's treatment of asthma acute stage of children is mainly to relieve phlegm and cough,reduce qi and asthma,and also to strengthen the spleen and strengthen the body resistance.