腹部脂肪定量评估在克罗恩病中的临床应用进展

Clinical progresses in quantitative evaluation of visceral adipose tissue in Crohn’s disease

克罗恩病(CD)是一种慢性非特异性炎症性肠病,其发病机制不明,可累及全胃肠道,随病程发展可出现肠道狭窄、穿孔、瘘管等多种并发症。而脂肪组织,特别是肠系膜脂肪被认为在CD的发病及病程进展中有重要作用,与疾病的活动性、严重程度以及预后密切相关。目前常规CT、能谱CT、MRI以及影像组学方法已用于CD病人腹部脂肪的定量评估,对这些影像技术方法及其临床应用进展予以综述。

Advancem Crohn’s disease(CD) is a chronic non-specific inflammatory bowel disease with unclear pathogenesis, it can involve the entire digestive tract. As the disease progresses, multiple complications such as intestinal stenosis,perforation, and fistula may occur. Adipose tissue, especially mesenteric fat, is considered playing an important role in the pathogenesis and progression of CD. Adipose tissue is closely related to the activity, severity and prognosis of the disease. At present, conventional CT, energy spectral CT, MRI, and radiomics methods have been used for the quantitative assessment of abdominal fat in CD patients. These imaging techniques and their clinical progresses are reviewed in this article.