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妊娠期牙周临床指标和龈沟液生物标记物与早产相关性的巢式病例对照研究 被引量:1

Association between periodontal indexes and biomarkers in gingival crevicular fluid and preterm birth in pregnancy:a nested case-control study
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摘要 目的探讨妊娠妇女牙周临床指标和龈沟液(GCF)生物标记物水平与早产的相关性,评价何种指标作为预测早产的可能性。方法采用巢式病例对照研究,纳入300例无系统疾病的妊娠36周以内的妇女,并按纳入时孕周数分组,检查牙周临床指标:探诊深度(PD)、出血指数(BI)、牙龈指数(GI);采用酶联免疫吸附测定法检测GCF生物标记物:前列腺素E2(PGE2)、白细胞介素(IL)-1β、IL-6、肿瘤坏死因子α(TNF-α)和8-羟基-2-脱氧鸟苷(8-OHdG),随访其妊娠结局。结果经1∶4配比,妊娠24~28周孕妇中,早产组的GI、BI以及8-OHdG显著高于巢式对照组(P<0.05)。经Logistic回归分析,BI和8-OHdG水平是早产的危险因素(OR=5.90,P=0.034;OR=1.18,P=0.045);绘制接受者操作特性曲线(ROC),BI、8-OHdG水平单项预测时ROC曲线下面积分别为0.80、0.69,二者联合检测的ROC曲线下面积为0.82,二者联合检测ROC曲线下面积大于单一检测,但差异无统计学意义(P>0.05)。结论妊娠24~28周BI和8-OHdG水平升高是早产的危险因素,二者联合检测可能对早产的预测有一定的价值,但需要进一步扩大样本进行研究,从而建立牙周病患者早产预警体系。 Objective This study aimed to investigate the association between periodontal indexes and biomarkers in gingival crevicular fluid(GCF)and preterm birth(PTB)in pregnancy,as well as to assess the clinical value of these indexes as predictors of PTB.Methods A nested case-control study was conducted.A total of 300 systematically healthy pregnant women were selected within 36 weeks of gestation and grouped according to the enrolled weeks.Periodontal indexes,including probing depth(PD),bleeding index(BI),gingival index(GI),and five biomarkers in GCF,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α(TNF-α),prostaglandin E2(PGE2),and 8-hydroxy-2-deoxyguanosine(8-OHdG)were measured at the enrolled date.The detailed birth outcome was recorded.Results Only women at 24-28 weeks of gestation per PTB case(four full-term births)were selected as controls subjects,PTB displayed significantly greater GI,BI,and 8-OHdG(P<0.05).Logistic regression analysis revealed that BI and 8-OHdG were the dependent risk factors of PTB(OR=5.90,P=0.034;OR=1.18,P=0.045,respectively).The areas under the receiver operating characteristic curve(ROC)of BI and 8-OHdG were 0.80 and 0.69,and that of the combined detection was 0.82,which was larger than the individual detection,although the differences were not significant(P>0.05).Conclusion Increased BI and 8-OHdG at 24-28 weeks of gestation are risk factors for PTB.Their combined detection may have some value in the prediction of PTB,but further studies with a larger sample size are needed to explore it and thus provide experiment evidence for establishing an early warning system for PTB in pregnant women with periodontal disease.
作者 叶婵娟 吴敏 陈少武 杨秀巧 李蕙君 朱素君 周方明 郝颖 Ye Chanjuan;Wu Min;Chen Shaowu;Yang Xiuqiao;Li Huijun;Zhu Sujun;Zhou Fangming;Hao Ying(Dept.of Stomatology,The Affiliated Shenzhen Maternity and Child Healthcare Hospital of the South Medical University,Shenzhen 518048,China;Dept.of Obstetrics and Gynecology,The Affiliated Shenzhen Maternity and Child Healthcare Hospital of the South Medical University,Shenzhen 518048,China;Clinical Laboratory,The Affiliated Shenzhen Maternity and Child Healthcare Hospital of the South Medical University,Shenzhen 518048,China)
出处 《华西口腔医学杂志》 CAS CSCD 北大核心 2021年第1期58-63,共6页 West China Journal of Stomatology
基金 深圳市科技创新委员会基础研究项目(JCYJ20160427-191204874)。
关键词 早产 牙周指标 龈沟液 炎症介质 预测 preterm birth periodontal index gingival crevicular fliud inflammatory mediators prediction
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