特异性促炎症消退介质在牙周炎中的研究进展

Developments of specialized pro-resolving mediators in periodontitis

炎症消退机制是机体维持稳态的重要途径,是一个涉及大量免疫细胞和介质的程序化的主动过程。特异性促炎症消退介质(SPM)包括消退素、保护素和噬消素(maresins),是Ω-3多不饱和脂肪酸衍生的一类内源性脂质介质,在促炎症消退、宿主防御、器官保护和组织再生方面都可发挥积极作用。牙周炎是以菌斑生物膜为始动因素的牙周组织炎症性、破坏性疾病。不完善的促炎或促炎症消退机制,以及两者之间的失衡状态是牙周炎病理进展的重要因素。SPM结合组织特异性受体能够改善牙周组织炎症状态,保护牙槽骨,促进组织再生,调节免疫细胞抵抗致病菌。本文就SPM对牙周炎的作用,应用前景及面临的挑战作一综述。

Resolution of inflammation plays an important part in maintaining homeostasis.It is an actively programmed progress involving multiple immune cells and mediators.Specialized pro-resolving mediators(SPMs)derived from Ω-3 polyunsaturated fatty acids include resolvins,protectins and maresins,and they exert abilities in the resolution of inflammation,host defense,organ protection,and tissue generation.Periodontitis is an inflammatory and destructive disease in the periodontal tissue initiated by dental plaque.Inadequate proinflammatory or proresolving responses,or the imbalance between the two,may contribute to the pathogenesis of the disease.Studies have shown that activating specialized receptors SPMs displayed multiple biological effects towards periodontitis,including resolution of inflammation,alveolar bone protection,periodontal tissue regeneration,and pathogen resistance.Thus,the relationship between SPM and periodontitis and the potentials and challenges in SPM application were reviewed.