辐射损伤唾液腺机制及治疗的研究进展

Advances on mechanism and treatment of salivary gland in radiation injury

颌面及颈部的恶性肿瘤是最常见的恶性肿瘤之一,治疗以手术治疗、放疗、化疗相结合为主,同时治疗存在着很多不良反应,如放疗存在诸多并发症,其中便以放射性唾液腺炎最为常见。此外还有口腔干燥、口腔黏膜炎、猛性龋、放射性颌骨骨髓炎等,导致吞咽、咀嚼问题以及味觉功能障碍等一系列变化。目前,放射性唾液腺炎的研究进展迅速,但其机制较为复杂,本文就此领域的相关研究成果作一综述。

Oral squamous cell carcinoma(OSCC)is the most frequent tumour in head and neck malignant.The current treatment is mainly based on surgery therapy,radiation therapy and chemical therapy.Meanwhile,there are many a defect in the treatment.For example,there are many defects in radiotherapy.Radioactive salivatitis is the most common.In addition,there are a series of changes such as dry mouth,oral mucositis,rampant dental caries,and radioactive osteomyelitis of jaw,which cause swallowing,chewing problems,and taste dysfunction.Currently,the research on radioactive salivatitis is progressing rapidly,but its mechanism is more complication.This paper review aims to summarize the research progress in this field.