阿尔茨海默病伴抑郁患者外周血炎性因子、25羟维生素D水平的研究

Serum Levels of Inflammatory Factors and 25-Hydroxyvitamin D in Alzheimer’s Disease Patient with Depression

目的探讨外周血炎性因子和25羟维生素D(25-OH-VD)水平在阿尔茨海默病(AD)伴抑郁患者诊疗中的临床意义。方法检测20例AD伴抑郁患者、26例AD无抑郁患者及24例符合入组条件健康志愿者外周血炎性因子和25-OH-VD水平,并运用简易智力状态检查表(MMSE)对受试者智力状态及认知功能进行评估。结果AD伴抑郁组IL-6、TNF-α水平显著增高,25-OH-VD水平显著降低,各组间差异有统计学意义(P<0.05)。Pearson相关性分析表明:AD伴抑郁组MMSE评分与IL-1β、IL-6、TNF-α水平呈负相关(r=–0.437、–0.371、–0.532,P<0.05);与25-OH-VD水平呈正相关(r=0.512,P<0.05);25-OH-VD与IL-1β、IL-6、TNF-α水平呈负相关(r=–0.452、–0.441、–0.471,P<0.05)。结论AD伴抑郁患者外周血炎性因子IL-6、TNF-α水平明显增高,25-OH-VD水平明显降低。这可能与AD患者认知缺陷有紧密联系。

Objective To determine the clinical significance of serum inflammatory markers and 25-hydroxyvitamin D in diagnosing and treating depression in patients with Alzheimer’s disease(AD).Methods Serum levels of inflammatory markers were measured by ELISA and 25 hydroxyvitamin D(25-OH-VD)by chemiluminescent immunoassay(CLIA)in 20 AD patients with depression,26 AD patients without depression and 24 eligible healthy volunteers.Participants were evaluated for cognitive function by the Mini-Mental State Examination(MMSE)scores.Results Serum levels of IL-6 and TNF-αin AD with depression group were significantly increased,and(25-OH-VD)was significantly decreased.There were significant differences between the three groups(P<0.01).Pearson correlation analysis showed that MMSE score in AD with depression group was negatively correlated with the levels of IL-1β、IL-6 and TNF-α(r=–0.437、–0.371、–0.532,P<0.05),and positively correlated with 25-OH-VD(r=0.512,P<0.05).(25-OH-VD)was negatively correlated with IL-1β,IL-6 and TNF-α(r=–0.452、–0.441、–0.471,P<0.05).Conclusion The marker levels of peripheral inflammatory IL-6 and TNF-αin AD patients with depression were significantly increased,and the level of(25-OH-VD)was significantly decreased.This may be closely related to cognitive impairment in AD patients.