血清CRP及PCT在高龄COPD合并医院获得性肺炎患者中的检测价值

Detection value of serum CRP and PCT in elderly patients with COPD and hospital acquired pneumonia

目的探究血清C反应蛋白(CRP)、降钙素原(PCT)在高龄慢性阻塞性肺疾病(Chronic obstructive pulmonary,COPD)合并医院获得性肺炎(hospital acquired pneumonai,HAP)患者中的检测价值。方法选取2018年5月—2019年6月河南省胸科医院收治的高龄COPD患者120例,按照其是否并发HAP将其分为观察组(并发HAP,n=54)和对照组(未并发HAP,n=66)两组,比较两组一般资料,抽取两组空腹静脉血并检测其血清CRP及PCT含量,采用ROC曲线分析血清CRP及PCT对高龄COPD合并HAP患者的检测价值。结果观察组男女性别比为32/22,平均年龄为(71.55±4.98)岁,脑血管疾病占比为11.11%,高血压疾病占比为24.07%;对照组男女性别比为(39/27),平均年龄为(71.97±5.45)岁,脑血管疾病占比为12.12%,高血压疾病占比为22.73%,两组一般资料差异无统计学意义(P>0.05)。观察组血清CRP水平为(74.33±10.21)mg/L,血清PCT水平为(3.61±1.14)μg/L,对照组血清CRP水平为(17.56±5.71)mg/L,血清PCT水平为(1.25±0.35)μg/L,观察组血清CRP及PCT水平均显著高于对照组(P<0.05)。ROC曲线分析显示,两者联合检测的检测价值(AUC=0.898)大于CRP(AUC=0.755)和PCT(AUC=0.809)单独检测(P<0.05)。结论血清CRP与PCT在高龄COPD合并HAP患者血清中呈显著高表达,血清CRP与PCT联合诊断高龄COPD合并HAP诊断价值高,具有临床应用价值。

Objective To explore the detection value of serum C-reactive protein(CRP) and procalcitonin(PCT) in elderly patients with chronic obstructive pulmonary(COPD) and hospital acquired pneumonia(HAP).Methods A total of 120 elderly COPD patients who were admitted to the hospital from May 2018 to June 2019 were enrolled. According to presence or absence of HAP, they were divided into observation group(n=54) and control group(n=66). The general data were compared between the two groups. The fasting venous blood was drew to detect contents of serum CRP and PCT in both groups. The detection value of serum CRP and PCT for elderly patients with COPD and HAP was analyzed by ROC curves.Results The ratio of males to females, average age, proportion of cerebrovascular diseases and hypertension in observation group were 32/22,(71.55±4.98) years old, 11.11% and 24.07%, which in control group were 39/27,(71.97±5.45) years old, 12.12% and 22.73%, respectively. There were no significant differences in the general data between the two groups(P>0.05). The levels of serum CRP and PCT in observation group were(74.33±10.21) mg/l and(3.61±1.14) ug/l, which in control group were(17.56±5.71) and(1.25±0.35), respectively. The levels of serum CRP and PCT in observation group were significantly higher than those of control group(P<0.05). ROC curve analysis showed that the detection value of CRP combined with PCT(AUC=0.898) was greater than that of CRP(AUC=0.755) and PCT(AUC=0.809) alone(P<0.05).Conclusion The serum CRP and PCT are significantly highly expressed in elderly patients with COPD and HAP. The diagnostic value of serum CRP combined with PCT is high for the elderly with COPD and HAP.