胆道闭锁Kasai手术后胆管炎病因的研究进展

Research advances in etiology of cholangitis after Kasai procedure

胆道闭锁Kasai术后胆管炎影响了患儿自体肝的生存状况,尤其是Kasai术后1年内反复发生的胆管炎,更易形成难治性胆管炎,严重影响了胆道闭锁Kasai手术的治疗效果。目前Kasai术后胆管炎病因尚不清楚,多数学者认为并非单一因素所致,与胆汁引流量下降、术后类固醇激素使用、肠道菌群移位、自身免疫损伤等因素密切相关。本文综述了胆道闭锁Kasai术后胆管炎发生的相关因素,为将来胆道闭锁的进一步治疗及Kasai术后胆管炎并发症的防治提供参考。

Cholangitis of biliary atresia(BA)after Kasai procedure(KP)affects the survival status of native liver in children.Especially cholangitis recurring within 1 year post-KP is more likely to become refractory.The etiology of BA has remained elusive.Most scholars believe that it is not caused by a single factor,but closely correlated with such factors as reduced bile drainage,postoperative steroid hormone use,intestinal flora shift and autoimmune damage.Reviewing the relevant factors of cholangitis of BA post-KP,this review provided a reference for future treatment of BA and prevention and management of cholangitis complications post-KP.