右美托咪定复合依托咪酯麻醉对胃癌根治术患者的效果观察及不良反应发生率影响分析

Effect of dexmedetomidine combined with etomidate anesthesia on patients undergoing radical gastrectomy and analysis of the incidence of adverse reactions

目的探究对胃癌根治术患者实施右美托咪定复合依托咪酯麻醉的效果及不良反应发生情况。方法随机将2017年1月至2019年5月新疆生产建设兵团第二师库尔勒医院64例胃癌根治术患者分为对照组(32例,应用依托咪酯)、实验组(32例,应用右美托咪定复合依托咪酯)。对比两组自主呼吸恢复时间、拔管时间、定向力恢复时间、认知功能评分及不良反应发生率。结果两组自主呼吸恢复时间无显著差异,P>0.05,但实验组拔管时间、定向力恢复时间较对照组更短,P<0.05;实验组术后6 h、术后12 h、术后24 h认知功能评分较对照组更高,P<0.05;实验组不良反应发生率(6.25%)低于对照组(31.25%),P<0.05。结论对胃癌根治术患者实施右美托咪定复合依托咪酯麻醉更有助于缩短拔管时间及定向力恢复时间,且对认知功能影响更小,安全性更高。

Objective To investigate the effect and adverse reactions of dexmedetomidine combined with etomidate anesthesia on patients undergoing radical gastrectomy.Methods From January 2017 to May 2019,64 cases of patients with radical gastrectomy in our hospital were randomly divided into two groups:control group(32 cases,etomidate)and experimental group(32 cases,etomidate combined with dexmedetomidine).The recovery time of spontaneous respiration,extubation time,directional force recovery time,cognitive function score,and the incidence of adverse reactions were compared between the two groups.Results There was no significant difference in the recovery time of spontaneous respiration between the two groups(P>0.05),but the recovery time of extubation and directional force in the experimental group was shorter than that in the control group(P<0.05);The cognitive function scores in the experimental group were higher than that in the control group(P<0.05)at 6 h,12 h and 24 h after operation;The incidence of adverse reactions in the experimental group(6.25%)was lower than that in the control group(31.25%),(P<0.05).Conclusions The anesthesia of dexmedetomidine combined with etomidate is more helpful to shorten the time of extubation and recovery of directional force and it has less effect on cognitive function and higher safety.