小柴胡汤合当归芍药散配合激光治疗糖尿病视网膜病变黄斑水肿临床研究

A Clinical Study of Xiaochaihu Decoction and Danggui Shaoyao Powder Combined with Laser on Macular Edema in Diabetic Retinopathy

目的:观察小柴胡汤合当归芍药散配合激光治疗糖尿病性黄斑水肿(DME)的临床疗效。方法:58例(100只眼)随机分为两组,对照组28例(47只眼)只接受视网膜激光光凝治疗,观察组30例(53只眼)接受视网膜激光光凝联合口服小柴胡汤合当归芍药散治疗。结果:治疗后3个月、6个月、9个月,两组BCVA均提高(P<0.05)。治疗后12个月,对照组BCVA无明显改善(P>0.05),观察组BCVA仍有所提高(P<0.05)。治疗后3个月、6个月,两组间BCVA改善无明显差异(P>0.05),治疗后9个月、12个月,观察组BCVA提高大于对照组(P<0.05)。观察组和对照组CMT均降低(P<0.05),且观察组低于对照组(P<0.05)。结论:小柴胡汤合当归芍药散联合激光治疗DME改善视功能、缓解黄斑水肿的远期疗效均优于单纯激光治疗,且未见不良反应。

Objective:To observe the clinical efficacy of Xiaochaihu Decoction and Danggui Shaoyao Powder combined with laser on diabetic macular edema(DME).Methods:Fifty-eight cases(100 eyes)were randomly divided into two groups.28 cases(47 eyes)in the control group only received retinal laser photocoagulation while 30 cases(53 eyes)in the observation group received retinal laser photocoagulation combined with oral Xiaochaihu Decoction and Danggui Shaoyao Powder.Results:3 months,6 months,and 9 months after treatment,the BCVA of both groups increased(P<0.05).After 12 months of treatment,the BCVA of the control group had no significant improvement(P>0.05),and the BCVA of the observation group still increased(P<0.05).At the time point of 3 months and 6 months after treatment,there was no significant difference in BCVA improvement between the two groups(P>0.05).At the time point of 9 months and 12 months after treatment,the BCVA increase in the observation group was greater than that in the control group(P<0.05).The CMT of the observation group and the control group decreased(P<0.05),and that of the observation group was lower than that of the control group(P<0.05).Conclusion:Xiaochaihu Decoction combined with Danggui Shaoyao Powder combined with laser has better long-term effect on DME than single use of laser in improving visual function and relieving macular edema,without adverse reaction.