单采血小板献血者铁蛋白状况调查与分析

Investigation and analysis of plasma ferritin levels in plateletpheresis donors

目的调查单采血小板献血者(以下简称献血者)的铁储存状况,为制定科学献血策略及服务献血者提供依据。方法对北京市红十字血液中心3 444例单采血小板献血者进行血浆铁蛋白检测结果分析,分别从性别、年龄、献血状态和近1年献血次数评估献血者铁蛋白状况。结果 3 444例单采血小板献血者铁蛋白低值率为26.63%,其中男性为26.75%、女性为26.31%,二者无统计学差异(P>0.05)。男性和女性初次单采血小板献血者不同年龄组别铁蛋白浓度和铁蛋白低值率均无统计学差异。随着献血次数增加,男性和女性献血者铁蛋白浓度均呈下降趋势、铁蛋白低值率均呈增高趋势。结论本研究多维度地分析了我国单采血小板献血者铁蛋白的基线数据,为下一步深入研究奠定了基础。献血前开展铁蛋白检测有助于降低献血者缺铁风险。

Objective We performed a prospective analysis of iron status in plateletpheresis donors, to provide data basis and support for optimizing the strategy of plateletpheresis donation and high quality service for donors. Methods Plasma ferritin levels were measured in samples from 3 444 plateletpheresis donors who donated in Beijing Red Cross Blood Center to evaluate iron status from the perspective of sex, age, donation status and number of donations in the past 12 months. Results 1) The incidence of low ferritin level was 26.63% in 3 444 cases. There was significant difference in the incidence of low ferritin between sex, as 26.75% in males and 26.31% in females(P>0.05), respectively. There was no significant difference in the concentration of ferritin and the incidence of low ferritin between different age groups of first-time donors. The concentration of ferritin declined and the incidence of low ferritin in males and females increased along with accumulated donations during the past 12 months. Conclusions This is a large study of ferritin testing in Chinese plateletpheresis donors from multiple dimensions, which laid a foundation for further researches. Ferritin screening is necessary and helpful to reduce the risk of iron deficiency in plateletpheresis donors.