铁蛋白降低的男性定期单采血小板捐献者的铁代谢指标的变化

The ferric metabolism of male regular plateletpheresis donors with plasma ferritin < 30 μg/L

目的探究铁蛋白<30μg/L出现储存铁降低的男性定期血小板献血者的铁代谢指标的变化情况。方法测定北京市红十字血液中心137例男性铁蛋白水平<30μg/L的定期血小板献血者铁代谢相关指标,包括游离铁(Fe)、血红蛋白(Hb)、不饱和铁结合力(UIBC)、总铁结合力(TIBC)、转铁蛋白(TRF)、前白蛋白(PALB),分析其与铁蛋白、献血总次数和近1年献血次数的关系。结果铁蛋白水平<30μg/L的男性定期血小板献血者相比于正常参考值UIBC有明显上升趋势,UIBC中位数水平为55.1μmol/L;血清铁有明显降低趋势,中位数水平为10.9μg/L;铁蛋白水平与铁代谢指标中的UIBC和Hb相关,铁代谢的各个指标之间普遍相关;近1年献血次数与TIBC、UIBC和TRF相关;献血总次数与TIBC和TRF相关。结论储存铁降低的男性定期血小板献血者出现铁代谢异常;对于男性定期进行血小板捐献的献血者须进行铁蛋白检测和铁代谢指标的协同检测共同评估铁缺乏状态。

Objective To investigate the variation of ferric metabolism indexes in male regular platetpheresis donors(MRPDs) with the low iron storage(plasma ferritin <30 μg/L). Methods The ferric metabolism indexes of 137 MRPDs with ferritin <30 μg/Lwere detected, including serum free iron(sFI), hemoglobin(Hb), unsaturated iron binding capacity(UIBC), total iron binding capacity(TIBC), transferrin(TRF) and prealbumin(PALB). The correlation between these indexes and the level of ferritin, the total number of platelet donation and the number of platelet donations in the previous year were analyzed. Results The UIBC of MRPDs with ferritin <30 μg/L showed a significant upward trendin comparison with the normal reference value,with the median level of UIBC at 55.1 μmol/L.The level of serum iron decreased significantly,with the median level at 10.9 μg/L. The level of ferritin was correlated with UIBC and Hb, and the indexes of iron metabolism were generally correlated to each other. The number of platelet donation in the previous year was correlated with TIBC, UIBC and TRF. The total number of platelet donation was correlated with TIBC and TRF. Conclusion MRPDs with ferritin <30 μg/L showed abnormalferric metabolism. It is necessary to detect both ferritin and ferric metabolism indexes to evaluate the iron deficiency in MRPDs.