摘要
为了研究铷(Rb)元素对CaO−SiO2−Na2O−B2O3−MgO−ZnO−P2O5系生物玻璃陶瓷的相组成、显微结构、力学性能和细胞响应的影响,设计加铷和不加铷的玻璃陶瓷成分。结果表明,在不含Rb的生物玻璃陶瓷基体中形成羟基磷灰石(HA)和Mg−白磷钙矿(Ca18Mg2H2(PO4)14)晶相;而添加Rb后,仅检测到HA相。添加Rb后,生物玻璃陶瓷中晶体的晶粒尺寸增大。添加Rb可以提高生物玻璃陶瓷的抗弯强度。细胞实验结果显示,含Rb的生物玻璃陶瓷具有更好的细胞粘附、增殖和碱性磷酸酶(ALP)活性。总之,含Rb玻璃陶瓷具有良好的力学性能、优良的生物活性和生物相容性,有望应用于骨再生领域。
In order to study the influence of rubidium(Rb)addition on the phase composition,microstructure,mechanical properties and cell response of bioactive glass-ceramics,CaO−SiO2−Na2O−B2O3−MgO−ZnO−P2O5 glass system was designed with and without addition of Rb.The results show that hydroxyapatite(HA)and Mg−whitelockite(Ca18Mg2H2(PO4)14)crystalline phases are formed in the glass matrix without Rb.After the addition of Rb,only HA phase is detected.The grain size of the crystals in the glass-ceramics is larger with the addition of Rb than that of samples without Rb.Rb addition can improve the bending strength of glass-ceramics.The cultivation of human bone marrow mesenchymal stem cells(hBMSCs)on Rb-containing glass-ceramics demonstrates enhanced cell adhesion,proliferation and ALP activity.In conclusion,Rb-modified glass-ceramics exhibit good mechanical property,excellent bioactivity and biocompatibility,which have potential for bone regeneration application.
作者
谭彦妮
陈文娟
韦伟
黄千里
和祥
Yan-ni TAN;Wen-juan CHEN;Wei WEI;Qian-li HUANG;Xiang HE(State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China)
基金
The authors are grateful for the financial supports from the Natural Science Foundation of Hunan Province,China(2019JJ50797)
the Postdoctoral Science Foundation of China(2019T120711).
