多索茶碱联合布地奈德治疗AE‐COPD的效果

The Effect of Doxofylline Combined With Budesonide in the Treatment of AE-COPD

目的探讨多索茶碱联合布地奈德治疗慢性阻塞性肺疾病急性加重期(AE‐COPD)的效果。方法选取2016年3月—2018年4月126例AE‐COPD患者,按就诊顺序分为观察组(n=63)和对照组(n=63),对照组采用布地奈德进行治疗,观察组采用多索茶碱联合布地奈德进行治疗,对比两组患者肺功能、炎症因子变化。结果治疗后,观察组FEV1、FEV1/FVC明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组IL-8、CRP均低于对照组,两组具有明显统计学意义(P<0.05)。结论多索茶碱联合布地奈德治疗AE‐COPD的效果显著,可有效改善患者肺功能、炎症因子。

Objective To investigate the effect of doxofylline combined with budesonide in the treatment of acute exacerbation of chronic obstructive pulmonary disease(ae-copd).Methods From March 2016 to April 2018,126 patients with AE-COPD were divided into observation group(n=63)and control group(n=63).Budesonide was used in the control group and doxofylline combined with budesonide was used in the observation group.The changes of pulmonary function and inflammatory factors were compared between the two groups.Results After treatment,FEV1 and FEV1/FVC in the observation group were significantly higher than those in the control group(P<0.05),and IL-8 and CRP in the observation group were lower than those in the control group(P<0.05).Conclusion Doxofylline combined with budesonide has a significant effect on the treatment of AE COPD,which can effectively improve the lung function and inflammatory factors.