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Ⅰ型血小板结合蛋白基序的去整合素金属蛋白酶-7在骨关节疾病发病机制中的研究进展 被引量:1

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摘要 Ⅰ型血小板结合蛋白基序的去整合素金属蛋白酶(ADAMTS)是一类新型锌离子依赖的金属蛋白酶家族,具有多种生理学功能。ADAMTS-7能抑制软骨细胞分化成熟,降解细胞外基质中的软骨寡聚基质蛋白(COMP),参与OA和RA的软骨损伤。在软骨或滑膜细胞中,ADAMTS-7可受包括TNF-α、IL-1β、IL-17A等在内的多种细胞因子调节,影响ADAMTS-7与软骨寡聚基质蛋白之间的相互作用。本综述的目的是更新ADAMTS-7在骨关节疾病发病机制中的作用。
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2020年第12期846-850,共5页 Chinese Journal of Rheumatology
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