盐酸纳美芬治疗急性重型颅脑损伤的疗效

Effect of nalmefene hydrochloride on acute severe craniocerebral injury

目的分析急性重型颅脑损伤患者采取盐酸纳美芬治疗的临床疗效。方法115例急性重型颅脑损伤患者,随机分为对照组(58例)和研究组(57例)。对照组患者给予常规治疗,研究组患者给予盐酸纳美芬治疗。对比两组患者治疗后5、15、20 d格拉斯哥昏迷量表(GCS)评分、美国国立卫生研究院卒中量表(NIHSS)评分及治疗后世界卫生组织与健康有关生存质量测定量表(WHOQOL)评分、BI指数。结果治疗后5、15、20 d,两组GCS评分组内比较差异具有统计学意义(P<0.05),随着治疗时间延长,两组GCS评分均不断上升;治疗后5、15、20 d,研究组患者GCS评分(4.6±0.5)、(8.7±1.5)、(14.8±0.2)分均高于对照组的(3.7±0.7)、(7.2±1.3)、(12.9±0.4)分,差异具有统计学意义(P<0.05)。治疗后5、15、20 d,两组NIHSS评分组内比较差异具有统计学意义(P<0.05),随着治疗时间延长,两组NIHSS评分均不断降低;治疗后5、15、20 d,研究组患者NIHSS评分均低于对照组,差异具有统计学意义(P<0.05)。治疗后,研究组患者生理、心理、社会、躯体、情感评分及BI指数均高于对照组,差异具有统计学意义(P<0.05)。结论对急性重型颅脑损伤患者采取盐酸纳美芬治疗能够有效提升患者的生活质量以及生活自理能力,同时能够改善脑神经功能缺损。

Objective To analyze the clinical efficacy of nalmefene hydrochloride on acute severe craniocerebral injury.Methods A total of 115 patients with severe craniocerebral injury were randomly divided into control group(58 cases)and research group(57 cases).The control group was treated with conventional therapy,and the research group was treated with nalmefene hydrochloride.The Glasgow coma scale(GCS),National Institutes of Health stroke scale(NIHSS)score after 5,15 and 20 d of treatment,and World Health Organization quality of life(WHOQOL)score,BI index after treatment were compared between the two groups.Results 5,15 and 20 d after treatment,there was statistically significant difference in GCS score between the two groups(P<0.05).As the treatment time prolonged,the GCS scores of the two groups continued to rise;5,15 and 20 d after treatment,the GCS score of the research group were(4.6±0.5),(8.7±1.5)and(14.8±0.2)points,which were higher than(3.7±0.7),(7.2±1.3)and(12.9±0.4)points of the control group,and the difference was statistically significant(P<0.05).5,15 and 20 d after treatment,there was statistically significant difference in NIHSS score between the two groups(P<0.05).As the treatment time prolonged,the NIHSS scores of the two groups continued to decrease;5,15 and 20 d after treatment,the NIHSS score of the research group was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the physical,psychological,social,physical,emotional scores and BI index of the research group were higher than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Nalmefene hydrochloride can effectively improve the quality of life and self-care ability of patients with acute severe craniocerebral injury,as well as the brain nerve function defect.