甲泼尼龙联合抗生素治疗重症肺炎的临床疗效观察

Observation on clinical efficacy of methylprednisolone combined with antibiotics in the treatment of severe pneumonia

目的分析甲泼尼龙联合抗生素治疗重症肺炎的临床疗效。方法82例重症肺炎患者,随机分为对照组与实验组,每组41例。对照组给予阿奇霉素静脉滴注治疗,实验组在对照组治疗基础上采取注射用甲泼尼龙琥珀酸钠治疗。比较两组患者治疗效果以及各项时间指标。结果实验组治疗总有效率92.68%高于对照组的60.98%,差异具有统计学意义(P<0.05)。实验组患者血气指标恢复时间(3.1±0.4)d、体温纠正时间(2.1±0.7)d、湿啰音消失时间(6.4±1.2)d、肺部阴影消失时间(5.4±1.1)d均短于对照组的(4.8±1.5)、(3.9±0.8)、(9.5±2.3)、(8.7±1.6)d,差异均具有统计学意义(P<0.05)。结论甲泼尼龙联合抗生素治疗重症肺炎的临床效果显著,能够加快患者的恢复。

Objective To analyze the clinical efficacy of methylprednisolone combined with antibiotics in the treatment of severe pneumonia.Methods A total of 82 patients with severe pneumonia were randomly divided into control group and experimental group,with 41 cases in each group.The control group was treated with intravenous infusion of azithromycin,and the experimental group was treated with methylprednisolone sodium succinate for injection on the basis of the control group.The therapeutic effect and time indicators were compared between the two groups.Results The total effective rate of treatment 92.68%of the experimental group was higher than 60.98%of the control group,and the difference was statistically significant(P<0.05).The recovery time of blood gas index(3.1±0.4)d,body temperature correction time(2.1±0.7)d,disappearance time of moist rales(6.4±1.2)d and disappearance time of lung shadow(5.4±1.1)d of the experimental group were shorter than(4.8±1.5),(3.9±0.8),(9.5±2.3)and(8.7±1.6)d of the control group,and the difference was statistically significant(P<0.05).Conclusion Methylprednisolone combined with antibiotics can accelerate the recovery of patients with severe pneumonia,and the curative effect is reliable.