摘要
心脏缺血性损伤是危害人类健康的重要原因,过去的干细胞疗法具有重要的功能缺陷,如免疫排斥、致瘤性和输注毒性等问题。大量研究表明,间充质干细胞的主要治疗作用是由旁分泌因子所介导。最新研究发现,间充质干细胞来源的外泌体microRNA从移植的干细胞转移至缺血损伤的心脏细胞,调节细胞的增殖、凋亡、炎症和血管生成。本文对来源于间充质干细胞的外泌体及其内部microRNA在心脏缺血性损伤修复中的分子机制进行综述。
Cardiac ischemic injuryseriously threatens human health.Previous stem cell therapy has following disadvantages,such as immune rejection,tumorigenicity and infusion toxicity.Previous studies showed that the therapy effect of stem cells transplantation is mainly mediated by paracrine factors.Recent studies have found that stem cell-derived exosome microRNAs are transferred from transplanted stem cells to recipient heart cells and can regulate cell proliferation,apoptosis,inflammation and angiogenesis.Here we reviewed the molecular mechanism of exosomes and the internal microRNAs incardiac ischemic injury repair.
作者
曹润峰
葛俊文
方霞
沈立
Cao Runfeng;Ge Junwen;Fang Xia;Shen Li(Department of Cardiothoracic Surgery,Shanghai Children's Hospital,Shanghai Jiao Tong University,Shanghai 200062,China;Tissue Engineering Laboratory of the Ninth People s Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China)
出处
《中华细胞与干细胞杂志（电子版）》
2021年第1期40-47,共8页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
国家自然科学基金(81371449)。
