天麻钩藤饮与氟桂利嗪治疗偏头痛有效性及安全性的Meta分析

Meta analysis of the effectiveness and safety of Tianma Gouteng drink and flunarizine in the treatment of migraine

目的使用Meta分析评价天麻钩藤饮与氟桂利嗪治疗偏头痛有效性及安全性。方法采用PubMed、Cochrane Library、知网(CNKI)、维普(VIP)和万方数据库进行文献检索。根据纳入及排除标准筛选出天麻钩藤饮与氟桂利嗪治疗偏头痛的随机对照试验(RCTs),采用RevMan 5.4软件进行Meta分析。结果共纳入11篇文献,总样本量902例。Meta分析显示,与单用氟桂利嗪相比,天麻钩藤饮治疗偏头痛能提高总有效率[RR=1.32,95%CI(1.24,1.40),P<0.00001];天麻钩藤饮可明显改善患者的生活质量[MD=6.74,95%CI(2.80,10.68),P=0.0008]。结论天麻钩藤饮治疗偏头痛的临床疗效优于氟桂利嗪,且可改善患者的生活质量,安全性更高。

Objective To evaluate the effectiveness and safety of Tianma Gouteng drink and flunarizine in the treatment of migraine by Meta analysis.Methods PubMed,Cochrane Library,CNKI(CNKI),VIP(VIP)and Wanfang database were used for literature retrieval.According to the inclusion and exclusion criteria,the randomized controlled trials(RCTs)of Tianma Gouteng drink and flunarizine in the treatment of migraine were selected,and the RevMan 5.4 software was used for Meta analysis.Results A total of 11 articles were included,with a total sample size of 902 cases.Meta analysis shows that compared with flunarizine alone,Tianma Gouteng drink can improve the total effective rate in the treatment of migraine[RR=1.32,95%CI(1.24,1.40),P<0.00001];Tianma Gouteng drink can significantly improve the quality of life of patients[MD=6.74,95%CI(2.80,10.68),P=0.0008].Conclusion Tianma Gouteng drink is superior to flunarizine in the treatment of migraine,and can improve the quality of life of patients,with higher safety.