桃红四物汤加味预防股骨粗隆间骨折PFN-A术后下肢深静脉血栓的临床效果

Clinical effect of modified Taohong Siwu decoction on prevention of deep venous thrombosis of lower limbs after PFN-A for intertrochanteric fracture of femur

目的探讨桃红四物汤加味预防股骨粗隆间骨折防旋股骨近端髓内钉术(PFN-A)术后下肢深静脉血栓的临床效果。方法将50例行PFN-A术治疗的股骨粗隆间骨折患者按照术后用药方式分为观察组(25例,桃红四物汤加味+低分子肝素)与对照组(25例,低分子肝素)。比较两组的临床效果。结果术后7、14 d,观察组的PT、APTT长于对照组,FIB、D-二聚体水平、VAS评分均低于对照组(P<0.05)。术后14 d,观察组的Hb水平、PCV、AI均低于对照组(P<0.05)。观察组的血栓形成率低于对照组(P<0.05)。结论桃红四物汤加味能有效改善股骨粗隆间骨折患者PFN-A术后血液高凝状态,缓解疼痛,降低下肢深静脉血栓发生率。

Objective To investigate the clinical effect of modified Taohong Siwu decoction on prevention of deep venous thrombosis of lower limbs after proximal femoral nail antirotation(PFN-A)for intertrochanteric fracture of femur.Methods A total of 50 patients with intertrochanteric fracture of femur treated by PFN-A were divided into observation group(25 cases,Taohong Siwu decoction+low molecular weight heparin)and control group(25 cases,low molecular weight heparin)by the way of postoperative medication.The clinical effects of the two groups were compared.Results At 7 and 14 d after operation,PT and APTT in the observation group were longer than those in the control group,FIB,D-dimer levels and VAS score were lower than those in the control group(P<0.05).At 14 d after operation,Hb level,PCV and AI in the observation group were lower than those in the control group(P<0.05).The thrombosis rate in the observation group was lower than that in the control group(P<0.05).Conclusion Modified Taohong Siwu decoction can effectively improve the hypercoagulable state of blood,relieve pain and reduce the incidence of deep venous thrombosis of lower limbs in patients with intertrochanteric fracture of femur after PFN-A.