63例成人无精子症AZFc缺失患者的临床特点及其与性激素水平相关性分析

Association of clinical features with sex hormone levels in 63 azoospermic patients with microdeletion of azoospermia factor C region

目的探讨无精子症无精子因子C区域(Azoospermia factor C region,AZFc)缺失患者的临床特点及其与性激素的相关性。方法回顾性分析63例无精子症并AZFc缺失患者的临床资料,包括年龄、身高、体重、体重指数(BMI)、睾丸体积和性激素。结果无精子症AZFc缺失组患者身高、体重、睾丸体积与精液正常组差异有统计学意义(P<0.05);2组FSH、LH、睾酮、催乳素水平差异也有统计学意义(P<0.05)。BMI与雌二醇呈正相关(r=0.327,P=0.009),与FSH呈负相关(r=-0.251,P=0.04);年龄与睾酮呈负相关(r=-0.256,P=0.04);睾丸体积与FSH呈负相关(r=-0.289,P=0.02);身高与睾酮、雌二醇、FSH、LH无相关性(P>0.05)。结论无精子症AZFc缺失患者更容易出现体重超标现象,容易更早期出现雄激素水平的下降,生活方式的调整和补充睾酮可能对该类患者的长期生活质量有益。

Objective To analyze the clinical features of 63 azoospermic patients with microdeletion of azoospermia factor C region(AZFc)and their relationship with sex hormones.Methods The clinical data of 63 azoospermic patients with AZFc microdeletion were retrospectively analyzed,including age,height,body weight,body mass index(BMI),testicular volume,and sex hormones.Results Compared with normozoospermic men,height,body weight,and testicular volume revealed statistical differences in azoospermic patients with AZFc microdeletion(P<0.05).There were significant differences in FSH,LH,testosterone(T),and prolactin levels between two groups(P<0.05).BMI was negatively associated with FSH level(r=-0.251,P=0.04)and positively associated with estradiol(E2)level(r=0.327,P=0.009).Age had a negative association with T level(r=-0.256,P=0.04).Testicular volume revealed a negative association with FSH level(r=-0.289,P=0.02).There were no association of height with T,E2,FSH,and LH levels(P>0.05).Conclusion It is more likely that azoospermic patients with AZFc microdeletion present overweight and earlier decreased androgen level.The adjustment of lifestyle and testosterone supplementation might be beneficial to the long-term quality of life in these patients.