糖皮质激素所致生长障碍研究新进展

Research advances in glucocorticoid-induced growth retardation

糖皮质激素是多种儿科疾病的重要治疗药物,其对骨骼系统的不良反应主要表现在三方面:骨质疏松、股骨头坏死和生长障碍。其中糖皮质激素所致的生长障碍导致终身高降低,是儿童患者治疗中需格外关注的问题。糖皮质激素引起生长障碍的机制复杂,且目前没有安全有效的治疗方法。本文总结了有关糖皮质激素抑制纵向骨生长的机制,并对近年来发现的潜在治疗靶点进行综述。

Glucocorticoid is an important treatment for many pediatric diseases and it often leads to osteoporosis,osteonecrosis of the femoral head,and growth retardation.Among them,glucocorticoid-induced growth retardation has been a particular focus in the treatment of children patients,which leads to a decrease in final height.The mechanism of glucocorticoid-induced growth retardation is complex,and there is no safe and effective treatment.This article summarized the mechanisms underlying glucocorticoid-inhibited longitudinal bone growth and reviewed the potential therapeutic targets discovered in recent years.