宫颈癌筛查人群中HPV感染情况与宫颈病变的相关性分析

Correlation Analysis of HPV Infection and Cervical Lesions in Women with Cervical Cancer Screening

目的:分析宫颈癌筛查人群中HPV感染情况与宫颈病变的相关性。方法:收集2017年6月—2019年6月至本院进行宫颈癌筛查的妇女1052例的临床资料,所有妇女均接受人乳头状瘤病毒(HPV)基因检测和薄层液基制片细胞学检测(TCT),HPV初筛提示为阳性者,经HPV基因分型检测获得明确的亚型结果,必要时进行阴道镜检查,获得宫颈组织病理学诊断。统计HPV阳性率和HPV亚型分布特征,计算单一感染率和多重感染率,分析不同年龄段人群HPV感染情况以及HPV亚型分布与宫颈病理结果的相关性。结果:HPV阳性率为29.0%;共检出12种高危亚型,4种低危亚型,高危亚型中HPV52位居第一,低危亚型中HPV4位居第一;单一HPV感染223例(73.1%),多重感染82例(26.9%)。31~40岁者HPV阳性率最高,其次为≤25岁者,>60岁者HPV阳性率最低。阴道镜检查病理结果阳性者31例,其中>60岁者病理结果阳性率最高。HPV52亚型感染所致病理结果为阳性者最多,低危亚型感染者中未发现导致病理结果为阳性者。结论:HPV筛查和亚型检测在女性宫颈癌筛查中具有重要的临床意义,可预测宫颈病变发生和程度,加强老年人群的宫颈癌筛查力度至关重要。

Objective:To analyze the correlation between HPV infection and cervical lesions in women with cervical cancer screening.Methods:The clinical data of 1052 women with cervical cancer screening in our hospital from June 2017 to June 2019 were collected.All women received human papillomavirus(HPV)gene detection and thin layer liquid based cytology(TCT).If HPV screening showed positive,the HPV genotyping test could obtain the definite subtype results.If necessary,colposcopy was performed to obtain the histopathological diagnosis of cervix.The HPV positive rate and HPV subtype distribution characteristics were statistically analyzed.The incidence of single infection and multiple infection was calculated.The HPV infection situation of different age groups and the correlation between HPV subtype distribution and cervical pathological results were analyzed.Results:The positive rate of HPV was 29.0%;12 high-risk subtypes and 4 low-risk subtypes were detected.HPV52 ranked first in high-risk subtypes and HPV4 in low-risk subtypes;223 cases(73.1%)were single HPV infection and 82 cases(26.9%)were multiple infection.The positive rate of HPV was the highest in 31~40 years old group,followed by≤25 years old group,and the lowest in 60 years old group.There were 31 cases with positive results of colposcopy,among which the positive rate of pathological results of patients over 60 years old was the highest.HPV52 subtype infection is caused by pathological results of the most positive,low-risk subtypes of infection did not lead to positive pathological results.Conclusion:HPV screening and subtype detection have important clinical significance in female cervical cancer screening,which can predict the occurrence and degree of cervical lesions,and it is very important to strengthen cervical cancer screening in elderly people.