环境内分泌干扰物对雄性动物生殖系统多代及跨代效应

Multigenerational and cross-generational effect of environmental endocrine disruptors on reproductive system in male animals

环境内分泌干扰物(EDCs)是一种能干扰内源性激素作用的外源性化学物质或化学混合物,可对发育中的机体组织产生危害。在亲代暴露者接触EDCs暴露一定时间后,化合物可能对子代造成不利影响,即化合物的多代及跨代效应。目前,大多数报道均涉及母体接触导致的子代多代及跨代效应,有研究显示,父系暴露后对雄性后代同样可能产生不良效应。EDCs对雄性动物具有一定的生殖毒性,但父系暴露后对雄性子代的生殖影响尚无明确定论。本文针对双酚A、邻苯二甲酸盐、二英类化合物和阿特拉津4种环境内分泌干扰物进行综述,探讨其对雄性动物的生殖毒性,以及父系暴露后对雄性后代产生的生殖相关多代及跨代效应。

Environmental endocrine disruptors(EDCs)are exogenous chemical compounds interfering with the activity of endogenous hormones,and can cause harm to development of tissues including reproductive system.After parents exposed to EDCs for a certain period of time,the offspring may be also affected by the chemical compounds,which is called multigeneration and cross-generation effects.Most recent researches are related to the multi-generation and cross-generation effects of maternal exposure and some studies also suggest that paternal exposure may have adverse effects on male offspring.EDCs have been found having certain reproductive toxicity to male animals,but its reproductive effect on male offspring after paternal exposure is undefined.This study reviews researches on reproductive toxicity of bisphenol A,phthalates,dioxin-like compounds and atrazine to male animals,as well as the reproduction-related multigenerational and cross-generational effects of paternal exposure to those chemicals on male offsprings.