急性白血病患者红细胞生成素及EPOR的表达及其临床意义

Expression of erythropoietin and EPOR in patients with acute leukemia and its clinical significance

目的分析急性白血病患者红细胞生成素(EPO)及红细胞生成素受体(EPOR)的表达及其临床意义。方法选取本院2018年2月至2019年7月收治的急性白血病患者80例,其中急性髓系白血病患者(AML组)与急性淋巴细胞白血病(ALL组)各40例,并选择同期收治的40例非血液系统疾病患者作为对照组。比较3组EPO、EPOR表达情况。结果ALL组、AML组骨髓血浆中的EPO表达明显高于对照组,EPOR表达明显低于对照组,差异有统计学意义(P<0.05);ALL组、AML组骨髓血浆中的EPO mRNA、EPOR mRNA水平均明显高于对照组(P<0.05);ALL组、AML组骨髓血浆中的EPO、EPOR蛋白水平明显高于对照组(P<0.05)。结论急性白血病患者的EPO、EPOR呈高表达,可根据EPO、EPOR表达量判断患者预后。

Objective To analyze the expression and clinical significance of erythropoietin(EPO)and erythropoietin receptor(EPOR)in patients with acute leukemia.Methods From February 2018 to July 2019,80 patients with acute leukemia were selected from our hospital,including 40 patients with acute myeloid leukemia(AML)and 40 patients with acute lymphoblastic leukemia(all),and 40 patients with non hematological diseases were selected as the control group.The EPO and EPOR expression among three groups were compared.Results The expression of EPO in bone marrow plasma of the ALL group and AML group were significantly higher than that of the control group,and the expression of EPOR was significantly lower than that of the control group,and the difference was statistically significant(P<0.05);the levels of EPO mRNA and EPOR mRNA in the bone marrow plasma of the ALL group and AML group were significantly higher than those of the control group(P<0.05);the expression of EPO and EPOR protein in bone marrow plasma of the ALL group and AML group were significantly higher than that of the control group(P<0.05).Conclusion The expression of EPO and EPOR is high in patients with acute leukemia,and the prognosis can be judged according to the expression of EPO and EPOR.