补肾填精法治疗多系统萎缩致体位性低血压疗效及对患者自主神经功能的影响

Effect of Bushen Tianjing therapy on postural hypotension caused by multiple system atrophy and its influence on autonomic nerve function

目的:探讨补肾填精法治疗多系统萎缩(MSA)致体位性低血压(OH)的疗效及对患者自主神经功能的影响。方法:选取MSA患者80例,随机分为观察组和对照组各40例。对照组给予单纯西药对症治疗,观察组在对照组用药基础上给予补肾填精法治疗。比较两组治疗前后卧立位收缩压差、卧立位舒张压差、肛门括约肌肌电图(EAS-EMG)情况、交感皮肤反应(SSR)情况及临床疗效。结果:治疗后,两组卧立位收缩压差、卧立位舒张压差值均明显减少,观察组更明显(均P<0.05)。治疗后,两组自发电位出现率、募集电位单纯相出现率及MUP平均时限均明显降低,且观察组更明显(均P<0.05)。观察组治疗总有效率高于对照组(P<0.05)。治疗后,两组SSR潜伏期缩短,波幅增高,且观察组更明显(均P<0.05)。结论:补肾填精法可改善多系统萎缩致体位性低血压患者的直立性低血压症状,促进患者自主神经功能康复,改善临床症状,临床疗效较为满意,且安全性高。

Objective:To investigate the therapeutic effect of Bushen Tianjing method on postural hypotension(OH)in patients with multiple system atrophy(MSA)and its influence on autonomic nerve function.Methods:80 patients with MSA were randomly divided into observation group(40 cases)and control group(40 cases).The control group was given western medicine symptomatic treatment,and the observation group was given Bushen Tianjing therapy on the basis of the control group.Results:After treatment,the difference of systolic pressure and diastolic blood pressure in supine and upright position of the two groups decreased significantly,especially in the observation group(all P<0.05).After treatment,the rate of spontaneous potential,the rate of single phase of recruitment potential and the average time limit of MUP in the two groups were significantly reduced,and the observation group was more obvious(all P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the latency of SSR in the two groups was shortened and the amplitude was increased,and the observation group was more obvious(P<0.05).Conclusion:The method of Bushen Tianjing can improve the symptoms of orthostatic hypotension in OH patients,promote the recovery of autonomic nerve function and improve the clinical symptoms.The clinical efficacy is satisfactory and the safety is high,which is worthy of further application and promotion.