叙利亚仓鼠应用于病毒感染性疾病动物模型的研究进展

Research progress of Syrian hamsters applied to animal models of viral infectious diseases

全球传染病致死的主要病因是病毒感染。建立一种类似临床人类病毒感染性疾病的动物模型,对病毒感染的致病机制、预防与治疗研究有重要意义。近年来叙利亚仓鼠多用于病毒感染性疾病的研究,其作为动物模型的价值和优势突显出来。本文从叙利亚仓鼠的生理学和免疫学等方面阐述其主要生物学特征,并对叙利亚仓鼠在冠状病毒、副粘病毒、汉坦病毒和西尼罗河病毒等多种人类高致病新兴病毒感染性疾病动物模型的应用比较及优点概述,为病毒感染性疾病的研究提供科学依据。

The main cause of death from infectious diseases worldwide is viral infection.The establishment of an animal model similar with clinical human viral infectious diseases is of great significance for the study of the pathogenic mechanism,prevention and treatment of viral infections.In recent years,Syrian hamsters are mostly used for the study of viral infectious diseases,and their value and advantages as animal models are highlighted.In this paper,the main characteristics of Syrian hamsters are described from the physiological and immunological characteristics.The comparison in application and advantages for the animal models are summarized to provide a scientific basis for the research of viral infectious diseases.