沙眼衣原体Ⅲ型分泌系统效应蛋白研究进展

Research progress on Chlamydia trachomatis type Ⅲ secretion system effector proteins

沙眼衣原体(Chlamydia trachomatis,Ct)是专性细胞内致病菌,主要通过Ⅲ型分泌系统(type Ⅲ secretion system,T3SS)直接将效应蛋白分泌到宿主细胞。T3SS效应蛋白在Ct发育以及与宿主细胞相互作用中发挥重要作用,如调节宿主细胞肌动蛋白骨架、破坏免疫信号通路以及控制宿主细胞凋亡等。本文综述了沙眼衣原体T3SS效应蛋白最新研究进展。

Chlamydia trachomatis(Ct)is an obligate intracellular pathogen.Effector proteins are secreted into host cells through the type Ⅲ secretion system(T3SS).T3SS effector proteins play important roles in Ct development and interaction with host cells,such as regulating the host cell actin cytoskeleton,subverting immune signaling pathways and controlling apoptosis in host cells.This article reviews recent advances in research on Chlamydia trachomatis T3SS effector proteins.