摘要
阿尔茨海默病(Alzheimer's disease,AD)是老年期最常见的慢性病之一,同时也是造成老年人丧失日常生活能力的最常见疾病。因此,AD的发病机制一直是研究热点。脑微出血(cerebral microbleeds,CMBs)是脑小血管病影像学表型之一。越来越多的研究表明,CMBs在AD发病过程中起着重要作用。文章就CMBs在AD患者中的流行病学、CMBs的数量和部位与AD、CMBs与AD脑脊液生物标志物及载脂蛋白Eε4等位基因的关系进行了综述。
Alzheimer's disease(AD)is one of the most common chronic diseases in old age,and it is also the most common disease that causes the elderly to lose the ability of daily living.Therefore,the pathogenesis of AD has always been a research hotspot.Cerebral microbleeds(CMBs)are one of the imaging phenotypes of cerebral small vessel disease.More and more studies have shown that CMBs play an important role in the pathogenesis of AD.This article reviews the epidemiology of CMBs in AD patients,the relationship between the number and location of CMBs and AD,and the relationship between CMBs and AD cerebrospinal fluid biomarkers and apolipoprotein Eε4 alleles.
作者
陈莉
刘欢
邢晓娜
陈晓虹
Chen Li;Liu Huan;Xing Xiaona;Chen Xiaohong(Department of Neurology,the Affiliated People's Hospital of China Medical University,Shenyang 110015,China;Department of Neurology,Jinqiu Hospital of Liaoning Province,Shenyang 110016,China;Department of Internal Medicine,Luohu District People's Hospital,the Third Affiliated Hospital of Shenzhen University,Shenzhen 518001,China)
出处
《国际脑血管病杂志》
2020年第12期933-936,共4页
International Journal of Cerebrovascular Diseases
基金
辽宁省科学技术计划项目(2019-MS-200)。
关键词
脑出血
阿尔茨海默病
脑淀粉样血管病
认知障碍
痴呆
磁共振成像
载脂蛋白E
淀粉样β蛋白肽
生物标志物
危险因素
Cerebral hemorrhage
Alzheimer disease
Cerebral amyloid angiopathy
Cognition disorders
Dementia
Magnetic resonance imaging
Apolipoproteins E
Amyloidβ-peptides
Biomarkers
Risk factors
