尿酸与心血管疾病关系的研究进展

Advances in Research on Relationship between Uric Acid and Cardiovascular Diseases

尿酸是人体嘌呤代谢的终末产物,主要通过肾脏排出体外。随着人们生活方式的改变,高尿酸血症的发病率呈逐年上升趋势。大量研究表明尿酸与心血管疾病关系密切。综述尿酸的代谢、尿酸与常见心血管疾病的关系、尿酸参与心血管疾病的可能作用机制以及降尿酸药物对心血管的保护作用,以期为相关研究提供参考。

Uric acid(UA),the end-product of purine metabolism in human,is mainly excreted through the kidneys.With the change of our lifestyles,the incidence of hyperuricemia is getting higher every year.The close relationship between uric acid and cardiovascular disease(CVD)has been recognized from a number of studies.This review summarizes the metabolism of uric acid,the correlation between uric acid and CVD,the potential mechanism of uric acid involvement in CVD,as well as the protective effect of uric acidlowering drugs on CVD,aiming to provide evidence for related research.