维生素D与子痫前期发病的相关性研究进展

Progress of the correlation between vitamin D and preeclampsia

子痫前期作为妊娠期高血压疾病的一类,是引起孕产妇死亡的四大病因之一。充足的维生素D水平对于孕期母儿健康发挥重要作用。维生素D与子痫前期发病密切相关,其机制主要与在氧化应激、免疫、血压调节及表观遗传学等有关。维生素D补充可降低妊娠期合并症的发生,降低子痫前期发病风险,改善不良妊娠结局。今后需要开展高质量的临床研究来证实维生素D补充对子痫前期的益处,补充维生素D可能成为预防子痫前期行之有效的干预策略。

Preeclampsia as a group of hypertensive disorders during pregnancy, is one of the four leading causes of maternal death. Adequate vitamin D levels play an important role in maternal and child health during pregnancy. Vitamin D is closely associated with the onset of preeclampsia. Its mechanism is mainly related to oxidative stress, immunity, blood pressure regulation and epigenetics. Vitamin D supplementation can reduce the incidence of pregnancy complications, reduce the risk of preeclampsia, and improve adverse pregnancy outcomes. Future high-quality clinical studies are needed to confirm the benefits of vitamin D supplementation for preeclampsia. Vitamin D supplementation may be an effective intervention strategy to prevent preeclampsia.