多西环素联合调Q脉冲激光治疗轻、中度酒渣鼻的临床效果及安全性分析

Clinical effect and safety of doxycycline combined with Q-switched pulsed laser in the treatment of mild and moderate rosacea

目的分析多西环素联合调Q脉冲激光治疗轻、中度酒渣鼻的临床效果及安全性。方法选择2018年5月至2020年5月我院收治的150例轻、中度酒渣鼻患者作为研究对象,采用随机数字表法分为观察组(75例)和对照组(75例)。其中对照组采用多西环素治疗,观察组采用多西环素联合调Q脉冲激光治疗,对比两组临床疗效、临床症状缓解情况及安全性差异。结果观察组患者的治疗有效率为96%,显著高于对照组的77.33%,差异有统计学意义(P<0.05)。观察组患者治疗后皮损区炎症损伤计数和红斑、毛细血管扩张程度评分均优于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的研究者总体评分(IGA)均优于对照组,差异有统计学意义(P<0.05)。观察组患者不良反应发生率为5.33%,显著低于对照组的17.33%,差异有统计学意义(P<0.05)。结论多西环素联合调Q脉冲激光治疗轻、中度酒渣鼻不仅可以显著提升治疗效果,同时有利于降低不良反应发生率,安全性更高,临床推广价值显著。

Objective To explore the clinical effect and safety of doxycycline combined with Q-switched pulsed laser in the treatment of mild and moderate rosacea.Methods 150 cases of mild and moderate rosacea patients in our hospital from May 2018 to may 2020 were selected as the research objects,and were randomly divided into observation group(75 cases)and control group(75 cases).The control group was treated with doxycycline,and the observation group was treated with doxycycline combined with Q-switched pulsed laser.The clinical efficacy,clinical symptom relief and safety of the two groups were compared.Results The effective rate of the observation group was 96%,which was significantly higher than 77.33%of the control group(P<0.05).After treatment,the inflammatory injury count,erythema and telangiectasia score of the observation group were better than those of the control group(P<0.05).After treatment,the overall investigator score(IGA)of the observation group was better than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was5.33%,which was significantly lower than 17.33%of the control group(P<0.05).Conclusion Doxycycline combined with Q-switched pulsed laser in the treatment of mild to moderate rosacea can not only significantly improve the treatment effect,but also reduce the incidence of adverse reactions.Its safety is higher and its clinical value is significant.