半夏厚朴汤治疗反流性食管炎的理论机制探讨

Exploration on the theoretical mechanism of Banxia Houpu Decoction in the treatment of reflux esophagitis

反流性食管炎(RE)为消化系统常见疾病之一,目前现代医学治疗RE复发率居高不下,而中医药治疗RE逐渐显露出一定的优势。本文拟从半夏厚朴汤治疗RE的理论基础、半夏厚朴汤的立法处方架构及所含药物的药理作用等角度进行分析研讨,认为脾胃虚弱为本病发病基础,中焦气机升降失常为病机关键。半夏厚朴汤具有开郁化痰、降气和胃之效,其组方药物具有促进胃排空、改善炎症反应、减少反流及抗抑郁的药理作用,并基于“方证相应”的理论基础发挥作用,本文为半夏厚朴汤对RE发挥疗效作用提供了理论依据。

Reflux esophagitis(RE)is one of the common diseases of alimentary system.At present,the relapse rate of RE treated by modern medical is still high,while the traditional Chinese medicine treatment of RE gradually shows some advantages.This paper analyzes and discusses the theoretical basis of Banxia Houpu Decoction in the treatment of RE,the legislative framework of Banxia Houpu Decoction and the pharmacological effects of the drugs.It is considered that the deficiency of the spleen and stomach is the basis of the disease,and the key pathogenesis is the ascending and descending of qi movement of middle jiao.Banxia Houpu Decoction has the effects of resolving stagnation and dissipating phlegm,descending qi and harmonizing stomach.Its prescription medicine can promote gastric emptying,improve inflammatory reaction,reduce reflux and alleviate depression,and play a role based on the theoretical basis of“corresponding formula and evidence”.This paper provides a theoretical basis for Banxia Houpu Decoction to play a therapeutic effect on RE.