摘要
MECHANISM OF P53-INDUCED LNCRNA IN PRETECTING TUMOR CELL SURVIVAL DURING GLUCOSE STARVATION Mian Wu Hefei National Laboratory of Physical Science at Microscale School of Life Sciences,University of Science and Technology of China Hefei,Anhui 230027,China Due to Warburg effect,cancer cells prefer to metabolize glucose through aerobic glycolysis,which results in low efficiency of ATP production.It is reasonable to believe that tumor cells will rely more heavily on glucose uptake to make up insufficient energy produced from glycolysis.It is expected that,under glucose starvation,cancer cells will subject to more cell death than normal cells.Yet,even those solid tumors that are intermittently or constantly exposed to glucose deprivation were shown to grow vigorously.How tumors successfully cope with the glucose stress remains unclear.
